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首页> 外文会议>Annual conference of the International Society of Exposure Science >Critical and systematic evaluation of 2,4-dichlorophenoxyacetic acid (2,4-D) exposure data: quality and generalizability for human assessments
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Critical and systematic evaluation of 2,4-dichlorophenoxyacetic acid (2,4-D) exposure data: quality and generalizability for human assessments

机译：对2,4-二氯苯氧基乙酸（2,4-D）暴露数据的关键和系统的评估：质量和人类评估的通用性

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The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been commercially available since the 1940's and there are several decades' worth of data on levels of 2,4-D in food, air, soil, and water as well as in humans. Yet the robustness of these data for use in human exposure assessments has not been evaluated. Using three elements of the Biomonitoring, Environmental Epidemiology, and Short-lived Chemicals (BEES-C) instrument (avoidance of sample contamination, analyte stability, and urinary methods of matrix adjustment), we evaluate the quality of environmental- and biomonitoring-based 2,4-D data in the peer-reviewed published literature. We further explore issues of temporal variability in 2,4-D concentrations in environmental media and humans and the impact on our understanding of human exposures to 2,4-D. We present the results of our review of 156 publications using the BEES-C instrument and describe the need for greater transparency in quality control measures. We also discuss the impact of temporal variability and the sources of 2,4-D vary within the 2,4-D literature and the importance of distinguishing peak vs. background levels of exposure to 2,4-D. We finally describe the challenges for the exposure community associated with reaching consensus on how to address problems specific to short-lived chemical exposures in observational studies and the need for deeper conversations to advance our understanding of human exposures, and to allow interpretation of these data to catch up to analytical capabilities.
机译：自1940年代以来，除草剂2,4-二氯苯氧基乙酸（2,4-D）已有市售，关于食物，空气，土壤和水中2,4-D含量的数据也已有数十年的历史。和人类一样然而，尚未评估这些数据用于人体暴露评估的稳健性。利用生物监测，环境流行病学和短寿命化学品（BEES-C）仪器的三个要素（避免样品污染，分析物稳定性和尿液基质调整方法），我们评估了基于环境和生物监测的质量2 ，4-D数据已发表于同行评审的文献中。我们进一步探讨环境介质和人类中2,4-D浓度随时间变化的问题，以及对我们对人类暴露于2,4-D的理解的影响。我们介绍了使用BEES-C仪器对156种出版物进行审查的结果，并描述了提高质量控制措施透明度的必要性。我们还讨论了时间变异性的影响以及2,4-D文献中2,4-D的来源各不相同，以及区分暴露于2,4-D的峰值与背景水平的重要性。最后，我们描述了暴露社区面临的挑战，这些挑战与就观察研究中如何解决针对短期化学暴露的特定问题达成共识有关，以及需要进行更深入的对话以增进我们对人类暴露的理解，并允许对这些数据进行解释，以达到共识。赶上分析能力。

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