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首页> 外文会议>Conference on optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy >HSA/PSS Coated Gold Nanorods as Thermo-Triggered Drug Delivery Vehicles for Combined Cancer Photothermal Therapy and Chemotherapy
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HSA/PSS Coated Gold Nanorods as Thermo-Triggered Drug Delivery Vehicles for Combined Cancer Photothermal Therapy and Chemotherapy

机译：HSA / PSS涂层金纳米棒作为热触发药物输送工具，用于癌症光热疗法和化学疗法的联合

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Drug delivery systems combined multimodal therapy strategies are very promising in cancer theranostic applications. In this work, a new drug-delivery vehicles based on human serum albumin (HSA)-coated gold nanorods (GNR/PSS/HSA NPs) was developed. The success of coating was verified by transmission electron microscopy (TEM), zeta potential and fourier transform infrared spectroscopy (FTIR). Furthermore, it is demonstrated that doxorubicin (DOX) is successfully loaded among multilayered gold nanorods by the electrostatic and hydrophobic force, and DOX@GNR/PSS/HSA NPs were highly biocompatible and stable in various physiological solutions. The NPs possess strong absorbance in near-infrared (NIR) region, and high photothermal conversion efficiency for outstanding photothermal therapy applications. A bimodal drug release triggered by proteinase or NIR irradiation has been revealed, resulting in a significant chemotherapeutic effect in tumor sites because of the preferential drug accumulation and triggered release. Importantly, the in vitro and in vivo experiments demonstrated that DOX@GNR/PSS/HSA NPs, which combined photothermal and chemotherapy for cancer therapy, revealing a remarkably superior synergistic anticancer effect over either monotherapy. All these results suggested a considerable potential of DOX@GNR/PSS/HSANPs nano-platform for antitumor therapy.
机译：结合多模式治疗策略的药物输送系统在癌症治疗学应用中非常有前途。在这项工作中，开发了一种新的基于人血清白蛋白（HSA）涂层的金纳米棒（GNR / PSS / HSA NPs）的药物递送载体。涂层的成功通过透射电子显微镜（TEM），ζ电位和傅立叶变换红外光谱（FTIR）进行了验证。此外，已证明阿霉素（DOX）通过静电和疏水力成功地负载在多层金纳米棒中，并且DOX @ GNR / PSS / HSA NP在各种生理溶液中具有高度的生物相容性和稳定性。 NP在近红外（NIR）区域具有很强的吸收能力，并且在出色的光热疗法应用中具有很高的光热转换效率。已经揭示了由蛋白酶或NIR辐射触发的双峰药物释放，由于优先的药物蓄积和触发释放，导致在肿瘤部位具有显着的化学治疗作用。重要的是，体外和体内实验表明，DOX @ GNR / PSS / HSA NPs结合了光热疗法和化学疗法进行癌症治疗，显示出比任何一种单一疗法都明显优越的协同抗癌作用。所有这些结果表明，DOX @ GNR / PSS / HSANPs纳米平台在抗肿瘤治疗方面具有相当大的潜力。

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