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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Preliminary Study of Time to Recovery of Rat Sciatic Nerve from High Frequency Alternating Current Nerve Block
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Preliminary Study of Time to Recovery of Rat Sciatic Nerve from High Frequency Alternating Current Nerve Block

机译：从高频交流电神经阻滞恢复大鼠坐骨神经时间的初步研究

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High-Frequency alternating current nerve block has great potential for neuromodulation-based therapies. However, no precise measurements have been made of the time needed for nerves to recover from block once the signal has been turned off. This study aims to characterise time to recovery of the rat sciatic nerve after 30 seconds of block at varying amplitudes and frequencies. Experiments were carried out in-vivo to quantify recovery times and recovery completeness within 0.7 s from the end of block. The sciatic nerve was blocked with an alternating square wave signal of amplitude and frequency ranging from 2 to 9mA and 10 to 50 kHz respectively. To determine the recovery dynamics the nerve was stimulated at 100 Hz after cessation of the blocking stimulus. Electromyogram signals were measured from the gastrocnemius medialis and tibialis anterior muscles during trials as indicators of nerve function. This allowed for nerve recovery to be measured with a resolution of 10 ms. This resolution is much greater than previous measurements of nerve recovery in the literature. Times for the nerve to recover to a steady state of activity ranged from 20 to 430 milliseconds and final relative recovery activity at 0.7 seconds spanned 0.2 to 1 approximately. Higher blocking signal amplitudes increased recovery time and decreased recovery completeness. These results suggest that blocking signal properties affect nerve recovery dynamics, which could help improve neuromodulation therapies and allow more precise comparison of results across studies using different blocking signal parameters.
机译：高频交流电神经阻滞在基于神经调节的疗法中具有巨大潜力。但是，一旦信号关闭，就无法对神经从阻滞中恢复所需的时间进行精确的测量。这项研究的目的是表征以不同幅度和频率阻塞30秒后大鼠坐骨神经的恢复时间。进行体内实验以量化从区块结束后0.7 s内的恢复时间和恢复完成度。坐骨神经被振幅和频率分别为2到9mA和10到50 kHz的交替方波信号阻塞。为确定恢复动态，在停止刺激后，以100 Hz刺激神经。在试验过程中从腓肠肌内侧和胫前肌测量肌电信号，作为神经功能的指标。这样可以以10毫秒的分辨率测量神经恢复。该分辨率比文献中先前对神经恢复的测量结果要大得多。神经恢复到稳定活动状态的时间为20到430毫秒，而在0.7秒时的最终相对恢复活动大约为0.2到1。较高的阻塞信号幅度会增加恢复时间，并降低恢复完整性。这些结果表明，阻断信号特性会影响神经恢复动力学，这可能有助于改善神经调节疗法，并允许在使用不同阻断信号参数的研究中更精确地比较结果。

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