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首页> 外文会议>Society for Biomaterials annual meeting and exposition >Targeted combinatorial drug delivery using stimuli-responsive mesoporous silica nanoparticles for pancreatic ductal adenocarcinoma therapy
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Targeted combinatorial drug delivery using stimuli-responsive mesoporous silica nanoparticles for pancreatic ductal adenocarcinoma therapy

机译：使用刺激反应介孔二氧化硅纳米粒子靶向组合药物递送，用于胰腺导管腺癌治疗

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摘要

MSNs were synthesized, conjugated with chemotherapeutic drugs and targeting antibody. The drug conjugated nanoparticles were shown to be promising in delivering the drugs and exhibiting cytotoxic effects in vitro. The targeting ability of the TAB004 was demonstrated through in vitro in PDAC cells and in vivo mouse model. Finally, preliminary results in vivo with allograft mice showed promising therapeutic effects.
机译：合成MSN，与化疗药物和靶向抗体偶联。药物缀合的纳米颗粒显示出在体外递送药物和表现出细胞毒性作用方面很有希望。通过体外在PDAC细胞和体内小鼠模型中证明了TAB004的靶向能力。最后，同种异体移植小鼠体内的初步结果显示了有希望的治疗效果。

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