Integrating experiments and MD simulations to determine the degradation of poly-4-hydroxybutyrate for surgical suture applications

机译：集成实验和MD模拟以确定用于外科缝合应用的聚4-羟基丁酸酯的降解

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This study is important to establish the mechanism and type of degradation that occurs with bioresorbable fibers, particularly P4HB for surgical suture applications. Furthermore, the results will be used to elucidate the optimum properties needed for thermal processing, such as controlling the polymer processing, storage and sterilization conditions. The experimental analysis and MD simulations for P4HB are in progress, and the findings generated will be applied to identify other applications in the body as well as to other hydrolytically bioresorbable polymers.

机译：这项研究对于确定生物可吸收纤维（尤其是用于外科缝合应用的P4HB）发生降解的机理和类型非常重要。此外，该结果将用于阐明热加工所需的最佳性能，例如控制聚合物的加工，储存和灭菌条件。对P4HB的实验分析和MD模拟正在进行中，所产生的结果将用于识别体内的其他应用以及其他可水解生物吸收的聚合物。

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《Society for Biomaterials annual meeting and exposition》|2018年|590-590|共1页
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Radhika Vaid; Melissa A. Pasquinelli; Martin W. King;
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3. Study on the hydrolytic degradation of the segmented GL-b-[GL-co-TMC-co-CL]-b-GL copolymer with application as monofilar surgical suture [J] . Yolanda Marquez, Lourdes Franco, Pau Turon, Polymer Degradation and Stability . 2013,第12期

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4. Integrating experiments and MD simulations to determine the degradation of poly-4-hydroxybutyrate for surgical suture applications [C] . Radhika Vaid, Melissa A. Pasquinelli, Martin W. King Society for Biomaterials annual meeting and exposition . 2018

机译：将实验和MD模拟集成以确定外科缝合型应用的聚-4-羟基丁酸酯的降解
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Integrating experiments and MD simulations to determine the degradation of poly-4-hydroxybutyrate for surgical suture applications

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