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Magnetically Triggered Drug Release from Nanoparticles

机译：磁性触发药物从纳米粒子释放

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This study shows that magnetic nanoparticles loaded with cargo that is conjugated through thermally labile bonds release the cargo when the temperature is elevated in an AMF, creating a potent combination of hyperthermia and drug release. In the absence of AMF, the particles retain the cargo for many hours at body temperatures. Under AMF, a faster release rate is achieved, showing the potential for the cargo to be released in significant quantities only at the target area. With the advances which allow the use of AMF at and only at specific regions in the body, these particles are a promising platform for cancer treatment. Future work will focus on tuning the thermally-labile bonds and heating characteristics of the magnetic nanoparticles to increase the release rate in the AMF while still retaining the cargo for many hours at body temperature. Further development and characterization of magnetic particles with striking local heating properties will also resolve disputes in previous literature about the local heating effect and provide much greater control of drug release.
机译：这项研究表明，在AMF中温度升高时，负载有通过热不稳定键结合的货物的磁性纳米颗粒会释放出货物，从而形成热疗和药物释放的有效组合。在没有AMF的情况下，这些颗粒会在人体温度下将货物保留多个小时。在AMF下，可以实现更快的释放速度，这表明仅在目标区域大量释放货物的潜力。随着允许在身体的特定区域以及仅在身体的特定区域使用AMF的进步，这些颗粒是癌症治疗的有前途的平台。未来的工作将集中于调整磁性纳米粒子的热不稳定键和加热特性，以提高AMF中的释放速率，同时仍将货物在人体温度下保持多个小时。具有显着的局部加热特性的磁性颗粒的进一步开发和表征，也将解决先前文献中有关局部加热效应的争议，并提供对药物释放的更大控制。

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