Novel Synthesis of Iron-based Metal-Organic Framework for Site-specific Doxorubicin Delivery

机译：基于铁的金属有机骨架的新型合成，用于特定地点的阿霉素递送

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The new metal-organic framework (Fe@2,6-NDC) was successfully synthesized using a green facile microwave irradiation technique in 5 min. The resultant, MOFs particles had shown promising structural and physical properties as new drug nanocarriers including small particles size, large pore size, and a high degree of compatibility. Further experiments arising from these findings include: coating the MOF with a hydrophilic polymer to increase the blood circulation half-life, conjugating targeting moieties to the MOF surface (active-targeting), and conducting in vitro and in vivo cytotoxicity studies.

机译：使用绿色简便的微波辐射技术在5分钟内成功合成了新的金属有机骨架（Fe @ 2,6-NDC）。所得的MOFs颗粒已显示出令人鼓舞的结构和物理性质，作为新药纳米载体，包括小粒径，大孔径和高度相容性。从这些发现中得出的进一步实验包括：用亲水性聚合物包被MOF以增加血液循环半衰期，将靶向部分缀合到MOF表面（活性靶向），以及进行体外和体内细胞毒性研究。

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《Society for Biomaterials annual meeting and exposition》|2018年|624-624|共1页
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Mihad Ibrahim; Rana Sabouni; Ghaleb Husseini;
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4. Novel Synthesis of Iron-based Metal-Organic Framework for Site-specific Doxorubicin Delivery [C] . Mihad Ibrahim, Rana Sabouni, Ghaleb Husseini Society for Biomaterials annual meeting and exposition . 2018

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Novel Synthesis of Iron-based Metal-Organic Framework for Site-specific Doxorubicin Delivery

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