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首页> 外文会议>Society for Biomaterials annual meeting and exposition >Additive Effects of Biomolecular Supplementation in Mineralized Collagen Scaffolds for Bone Regeneration
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Additive Effects of Biomolecular Supplementation in Mineralized Collagen Scaffolds for Bone Regeneration

机译：生物分子补充剂在矿化胶原蛋白支架中的骨再生作用。

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Conclusions. We demonstrate that biomolecules can be added into our scaffolds and released steadily for 18 days in vitro. Continuing this work, we will examine cellular response to different growth factors (e.g. VEGF, PDGF) within the mineralized scaffolds to improve vessel formation and cellular recruitment. Furthermore, we demonstrate that zinc sulfate can be incorporated into the mineralized collagen scaffold. The incorporation of zinc sulfate did not affect pore microstructure, mechanical properties, mineral composition, or cell viability; however, there is a clear change in mineral organization within the mineralized zinc scaffolds. Differences in mineral morphology suggest that cells will interact with the scaffold differently; ongoing efforts will utilize critical point drying (CPD) and ESEM to visualize cell morphology within our scaffolds.
机译：结论我们证明了生物分子可以添加到我们的支架中，并在体外稳定释放18天。继续这项工作，我们将检查矿化支架中细胞对不同生长因子（例如VEGF，PDGF）的反应，以改善血管形成和细胞募集。此外，我们证明了硫酸锌可以掺入矿化的胶原蛋白支架中。硫酸锌的加入不会影响孔的微观结构，机械性能，矿物质组成或细胞活力。但是，矿化的锌支架中的矿物质组织发生了明显的变化。矿物形态的差异表明细胞与支架的相互作用不同。正在进行的工作将利用临界点干燥（CPD）和ESEM可视化我们支架中的细胞形态。

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