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首页> 外文会议>Conference on single-use technologies II: bridging polymer science to biotechnology applications >INCLINED PLATE SETTLERS WITH NOVEL RECEIVER SECTION AS A UNIT OPERATION FOR COMPLEX CONTINUOUS SOLID-LIQUID SEPARATION PROBLEMS
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INCLINED PLATE SETTLERS WITH NOVEL RECEIVER SECTION AS A UNIT OPERATION FOR COMPLEX CONTINUOUS SOLID-LIQUID SEPARATION PROBLEMS

机译：倾斜的板式沉降器，带有新的接收器部分，可作为单元操作来解决复杂的连续固液分离问题

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Solid-liquid separation has been identified as a bottle-neck in continuous processing, especially regarding precipitate collection. Previously, tangential flow filtration has been proposed as a means of solid-liquid separation that retains precipitate flock structure. We have developed a novel receiver section concept for inclined plate settlers. Inclined plate settlers have been described for cell retention in perfusion processes in the 1990s. Conventional plate settlers suffer from non-ideal flow distribution between the individual plates. 5,mixing effects in the receiver section and significant losses of solubilized product during withdrawal of the concentrated suspension. Consequently, conventional plate settlers are not suitable for applications outside of perfusion. We devised a novel receiver section concept employing a system of flow distributors, which overcomes the deficiencies in flow distribution and separation between inflowing suspension and sedimented solids. Furthermore, the novel concept enables wash of the collected solids and thus significantly reduces fluid carry-over into the (intermittent) discharge stream. Thereby, the application range of inclined plate settlers is expanded from cell-retention to solid-liquid separation in general. Both streams, clarified fluid as well as concentrated and washed solids, can leave the system. The separated solids can, but do not have to be returned to the process. Proof-of-concept was provided using a single plate inclined settler. Operation conditions of the inclined plate settler system were optimized for precipitated product harvest. Scale-up is demonstrated from one to multiple plates for cell removal. We demonstrated continuous operation for ～90h and once in steady-state, turbidity was reduced by 95 % at consistently high product yields.
机译：固液分离已被认为是连续加工的瓶颈，特别是在沉淀物收集方面。以前，已提出切向流过滤作为固液分离的一种方法，该方法可保留沉淀物的绒毛结构。我们为倾斜板沉降器开发了一种新颖的接收器部分概念。在1990年代，已经描述了倾斜的平板沉降器在灌注过程中用于细胞保留。常规的板沉降器在各个板之间存在非理想的流量分布。 5，在接收器部分的混合效果和浓缩悬浮液取出期间溶解产物的大量损失。因此，常规的平板沉降器不适用于灌注以外的应用。我们设计了一种采用流量分配器系统的新型接收器部分概念，该概念克服了流量分配以及流入的悬浮液与沉淀固体之间分离的缺陷。此外，该新颖概念使得能够洗涤所收集的固体，并因此显着减少了流体带入（间歇）排出流中的情况。因此，通常将斜板沉降器的应用范围从细胞保留扩展到固液分离。两种流，澄清的流体以及浓缩和洗涤的固体都可以离开系统。分离出的固体可以但不必返回到过程中。使用单板倾斜沉降器提供概念验证。优化了斜板沉降器系统的操作条件，以收集沉淀的产品。放大显示了从一块板到多块板的细胞去除效果。我们证明了连续运行约90小时后，一旦进入稳态，在始终如一的高产品产量下，浊度降低了95％。

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