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首页> 外文会议>Conference on single-use technologies II: bridging polymer science to biotechnology applications >SINGLE-USE PRIMARY CAPTURE TECHNOLOGY WITH THE PROMISE TO DELIVER NEW STANDARDS FOR THE ECONOMICS, CONVENIENCE AND RELIABILITY OF MAB BIOPROCESSING
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SINGLE-USE PRIMARY CAPTURE TECHNOLOGY WITH THE PROMISE TO DELIVER NEW STANDARDS FOR THE ECONOMICS, CONVENIENCE AND RELIABILITY OF MAB BIOPROCESSING

机译：单使用主要捕获技术，承诺为MAb生物处理的经济，便利性和可靠性提供新的标准

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摘要

Product capture chromatography has been crucial in the process development and manufacture of mAb therapeutics over the past 20 years, and in particular Protein A affinity. Chromatography is a step that has had a lot of process development time attributed to getting packed beds to perform to their maximum capability and most of the optimisation stems from limitations of the inherent media and its pack form, such as mass transfer & pressure drop limitations, channeling and bead-wall support effects. The limited throughput that this media offers has prevented this unit operation from being economically accessible in a single-use format.
机译：产品捕获色谱法在过去20年中，MAB治疗剂的过程开发和制造至关重要，特别是蛋白质是亲和力。色谱图是具有大量工艺开发时间的步骤，该过程归因于将包装的床用于其最大能力，并且大多数优化源于固有介质及其包装形式的限制，例如传质和压降限制，通道和珠壁支撑效果。该媒体提供的有限吞吐量阻止了该单元操作以单一使用格式在经济上可访问。

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