APPLICATION OF ALTERNATIVE CELL SEPARATION SYSTEMS FOR THE HARVEST OF MAMMALIAN CELL CULTURE PROCESSES IN A FULLY DISPOSABLE SINGLE-USE FACILITY

机译：替代细胞分离系统在完全一次性单用工具中收获哺乳动物细胞培养方法的应用

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In a fully disposable facility where the use of continuous disk-stack centrifuges are not preferred, harvest processes based on conventional depth filtration become more challenging with increasing single-use bioreactor (SUB) size and higher density culture. Lower filterability due to high volume and high cell density diminishes the efficiency of the depth filtration. In addition, the use of larger depth filtration systems is constrained by the facility footprint. To address the challenge described, several alternative single-use harvest technologies were evaluated.

机译：在不优选使用连续盘堆离心机的完全一次性设施中，基于常规深度过滤的收获过程随着单用生物反应器（子）尺寸和更高密度培养而变得更具挑战性。由于大容积和高电池密度降低了较低的过滤性降低了深度过滤的效率。此外，使用较大的深度过滤系统受设施占地面积的约束。为了解决所描述的挑战，评估了几种替代的单使用收获技术。

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《Conference on single-use technologies II: bridging polymer science to biotechnology applications》|2017年|199 p.|共1页
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Daniel Bock; Dominique Monteil; Jessica Maier; Kevin Michal; Jeffrey Kuan; Marcella Yu; Jon Coffman; Henry Lin; Meena George;
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1. Engineering characterisation of single-use bioreactor technology for mammalian cell culture applications [J] . Akinlolu Odeleye, Gary J Lye, Martina Micheletti BMC proceedings. . 2013,第S6期

机译：用于哺乳动物细胞培养的一次性生物反应器技术的工程表征
2. Engineering characterisation of single-use bioreactor technology for mammalian cell culture applications [J] . Akinlolu Odeleye, Gary J Lye, Martina Micheletti BMC proceedings. . 2013,第S6期

机译：用于哺乳动物细胞培养的一次性生物反应器技术的工程表征
3. Production of Oncolytic Adenovirus and Human Mesenchymal Stem Cells in a Single-Use, Vertical-Wheel Bioreactor System: Impact of Bioreactor Design on Performance of Microcarrier-Based Cell Culture Processes [J] . Sousa Marcos F. Q., Silva Marta M., Roldao Antonio, Biotechnology Progress . 2015,第6期

机译：一次性使用的垂直轮生物反应器系统中溶瘤腺病毒和人间充质干细胞的生产：生物反应器设计对基于微载体的细胞培养过程性能的影响
4. APPLICATION OF ALTERNATIVE CELL SEPARATION SYSTEMS FOR THE HARVEST OF MAMMALIAN CELL CULTURE PROCESSES IN A FULLY DISPOSABLE SINGLE-USE FACILITY [C] . Daniel Bock, Dominique Monteil, Jessica Maier, Conference on single-use technologies II: bridging polymer science to biotechnology applications . 2017

机译：替代性细胞分离系统在完全一次性使用设施中收集哺乳动物细胞过程的应用
5. Bioprocess equipment & methods for efficient processes: Cell culture, single-use technology, and costing methods for optimized bioprocessing operations [D] . Perrone, Pietro P. 2017

机译：用于高效过程的生物过程设备和方法：细胞培养，一次性技术和用于优化生物过程操作的成本核算方法
6. Engineering characterisation of single-use bioreactor technology for mammalian cell culture applications [O] . Akinlolu Odeleye, Gary J Lye, Martina Micheletti 2013

机译：用于哺乳动物细胞培养的一次性生物反应器技术的工程表征
7. Engineering characterisation of single-use bioreactor technology for mammalian cell culture applications [O] . Akinlolu Odeleye, Gary J Lye, Martina Micheletti 2013

机译：用于哺乳动物细胞培养的一次性生物反应器技术的工程表征

APPLICATION OF ALTERNATIVE CELL SEPARATION SYSTEMS FOR THE HARVEST OF MAMMALIAN CELL CULTURE PROCESSES IN A FULLY DISPOSABLE SINGLE-USE FACILITY

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