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首页> 外文会议>IEEE Portuguese Meeting in Bioengineering >Understanding network reorganization after glioma regrowth: comparing connectivity measures from functional magnetic resonance imaging to direct cortical stimulation
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Understanding network reorganization after glioma regrowth: comparing connectivity measures from functional magnetic resonance imaging to direct cortical stimulation

机译：了解神经胶质瘤再生后的网络重组：比较从功能磁共振成像到直接皮层刺激的连通性测量

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Task specific networks in the human brain can be complex and variable inter-individually. New tools such as connectivity analysis were prompt as useful for network evaluation in patients without structural brain disease. However, these tools lack clinical understanding and correlation. We aimed to analyze task specific connectivity measures in pre-surgical planning in patients with low grade gliomas and evaluate their changes after tumor regrowth. We recruited three patients submitted to awake craniotomy resection with direct cortical stimulation (DCS) guided by a navigational system. They performed functional magnetic resonance (fMRI) in pre-surgical planning and after tumor regrowth. Connectivity measures were extracted from motor and language tasks done during fMRI acquisition. We correlated connectivity with clinical evaluation, DCS finding's and compared with fMRI after tumor regrowth. We found a reduced participation coefficient in precentral gyri in a patient with reduced hand strength. Regarding language, homolateral and contralateral hemisphere reorganization was observed with higher participation coefficient or betweenness centrality. Functional connectivity measures provided insight about individual brain region's role in motor and language function in pre-surgical planning. Further understanding of brain reorganization was provided by connectivity analysis after tumor regrowth.
机译：人脑中的特定于任务的网络可能是复杂的，并且个体之间会有所不同。诸如连通性分析之类的新工具迅速提示对无结构性脑病的患者进行网络评估很有用。但是，这些工具缺乏临床理解和相关性。我们旨在分析低级神经胶质瘤患者术前计划中的任务特定连接性措施，并评估其在肿瘤再生后的变化。我们招募了三名在导航系统指导下接受直接皮层刺激（DCS）的清醒颅骨切除术患者。他们在手术前计划和肿瘤再生后进行了功能磁共振（fMRI）。连接度是从fMRI采集过程中完成的运动和语言任务中提取的。我们将连通性与临床评估，DCS发现相关联，并与肿瘤再生后的功能磁共振成像进行了比较。我们发现手力下降的患者中枢回回的参与系数降低。在语言方面，观察到同侧和对侧半球的重组具有较高的参与系数或中间性。功能连接性度量提供了有关单个脑区域在术前计划中在运动和语言功能中的作用的见解。肿瘤再生长后的连通性分析提供了对大脑重组的进一步了解。

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