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首页> 外文会议>International Conference on Recent Advances in Space Technologies >Lensless Digital in-Line Holographic Microscopy for Space Biotechnology Applications
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Lensless Digital in-Line Holographic Microscopy for Space Biotechnology Applications

机译：用于太空生物技术应用的无透镜数字直列全息显微镜

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Biomechanical changes at cellular level can dramatically affect living organisms in both aviation and space applications. Weightlessness induces morphological alteration of cells, which leads to tissue loss. Therefore, scientists have been studying the effect of weightlessness using cell culture based biological experiments using conventional microscopes. However, strict requirements regarding cost, weight and functionality limit the use of conventional microscopes in space environment. Lensless digital in-line holographic microscopy enables to use low-weight, low-cost and robust elements, such as a light emitting diode (LED), an aperture and an imaging sensor, instead of bulky, expensive and fragile optical elements, such as lenses, mirrors and filters. This technology offers a high field of view compared to conventional microscopes without affecting the resolution and it is also suitable for remote sensing applications with automated imaging capabilities. Here, we present a portable digital in-line holographic microscopy platform that allows to visualize cells and to analyze their viability in a microfluidic chip. The platform offers microscopic imaging with 1.55 μm spatial resolution, 21.7 mm2field of view and image coloring capability. This platform could potentially play an important role in space biotechnology applications by enabling low-cost, high-resolution and portable monitoring of cells.
机译：细胞水平上的生物力学变化会极大地影响航空和航天应用中的活生物体。失重会诱导细胞形态改变，从而导致组织损失。因此，科学家一直在使用基于细胞培养物的生物实验和常规显微镜研究失重的影响。但是，有关成本，重量和功能的严格要求限制了常规显微镜在太空环境中的使用。无透镜数字在线全息显微镜能够使用重量轻，成本低且坚固的元件，例如发光二极管（LED），光圈和成像传感器，而不是笨重，昂贵且易碎的光学元件，例如镜头，镜子和滤镜。与传统显微镜相比，该技术可提供较高的视野，而不会影响分辨率，它还适用于具有自动成像功能的遥感应用。在这里，我们提出了一种便携式数字在线全息显微镜平台，该平台可以可视化细胞并分析其在微流控芯片中的生存能力。该平台可提供空间分辨率为1.55μm，21.7 mm的显微成像 2 视野和图像着色能力。通过支持低成本，高分辨率和便携式细胞监测，该平台可能在空间生物技术应用中发挥重要作用。

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