• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>IEEE International Conference on Nano/Molecular Medicine Engineering >Fabrication and Testing of a Gold Nanoparticle-loaded Tissue-mimicking Phantom for Validation of Gold L-shell X-ray Fluorescence Imaging Results
【24h】

Fabrication and Testing of a Gold Nanoparticle-loaded Tissue-mimicking Phantom for Validation of Gold L-shell X-ray Fluorescence Imaging Results

机译：金纳米粒子加载的组织模拟幻影的制作和测试，用于验证金L壳X射线荧光成像结果

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We previously reported the development of direct x-ray fluorescence (XRF) imaging system for quantitative imaging of gold nanoparticles (GNPs) on a benchtop setting. This system is implemented with an ordinary polychromatic x-ray source and, by detecting gold $L$-shell XRF photons, is capable of detecting/imaging trace amounts of gold nanoparticles (GNPs), on the order of parts-per-million (ppm), under the calibration conditions. For routine XRF imaging of biological samples (e.g., explanted tumors) containing ppm-level GNPs, this system needs to be tested further under more realistic imaging conditions. Thus, we developed a GNP-loaded tissue-mimicking phantom and performed a phantom imaging study using our benchtop XRF imaging system. For the tissue-mimicking phantom construction, the GNP-filled capillary tubes with known GNP concentrations were placed in an “E” shaped pattern and sandwiched between three layers of cheese. The results (i.e., XRF map) from the scanning of this phantom showed that the “E” shape of the phantom was well visible in the XRF map and all three arms and the stem of “E” were spatially resolved within ∼2 mm. The measured GNP concentrations were in good agreement with the known GNP concentrations.
机译：我们先前曾报道过直接X射线荧光（XRF）成像系统的开发，用于在台式环境中对金纳米颗粒（GNP）进行定量成像。该系统用普通的多色X射线源实现，并通过检测金 $ L $ 壳XRF光子能够在校准条件下检测/成像痕量的金纳米颗粒（GNP），其量级为百万分之一（ppm）。对于含有ppm级GNP的生物样品（例如外植肿瘤）的常规XRF成像，需要在更真实的成像条件下对该系统进行进一步测试。因此，我们开发了装有GNP的组织模拟体模，并使用台式XRF成像系统进行了体模成像研究。对于模仿组织的幻像构造，将具有已知GNP浓度的GNP填充毛细管放置为“ E”形图案，并夹在三层奶酪之间。扫描该体模的结果（即XRF图）显示，体模的“ E”形在XRF图中清晰可见，并且“ E”的所有三个臂和茎在约2 mm内在空间上分辨。测得的GNP浓度与已知的GNP浓度高度吻合。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号