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首页> 外文会议>International Conference on Transparent Optical Networks >Tapered Fibers for Optogenetics: Gaining Spatial Resolution in Deep Brain Regions by Exploiting Angle-Selective Light Injection Systems
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Tapered Fibers for Optogenetics: Gaining Spatial Resolution in Deep Brain Regions by Exploiting Angle-Selective Light Injection Systems

机译：用于光遗传学的锥形纤维：通过利用角度选择光注入系统获得深部大脑区域的空间分辨率

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摘要

This work describes a method to inject light into tapered optical fibers (TFs) in order to achieve site-selective and wide-volume optical control of neural activity with a single optical setup. The method relies on a Galvanometric – Resonant mirrors scan head, employed to inject light into the fiber to: (i) select a specific subset of guided modes obtaining localized illumination or (ii) to scan between the different guided modes at high-rate to obtain full NA-like light injection on time scales >0.2 ms. This is shown by analysing the light emission profiles from the TF with different voltage biases applied to the Galvanometric and the Resonant mirrors, and comparing them with a standard Full NA light-injection. With the aim to find the experimental parameters to obtain efficient Full NA – like emission profile, the Emission Length and the First Emission Diameter of TFs were extracted and compared with an ideal wide-volume emitter. Both Galvanometric and Resonant scanners methods shown a good agreement with the reference values of the standard Full NA injection, allowing neuroscientists to switch from site-selective to wide-volume illumination using a single optical setup.
机译：这项工作描述了一种将光注入锥形光纤（TFs）中的方法，以便通过单个光学设置实现对神经活动的位置选择和大容量光学控制。该方法依赖于振镜反射镜扫描头，该扫描头用于将光注入光纤以：（i）选择特定的导向模式子集以获得局部照明，或（ii）以高速率在不同的导向模式之间进行扫描，以达到在> 0.2 ms的时间范围内获得完全的类似NA的光注入。通过分析施加到检流镜和谐振镜的不同电压偏压下TF的发光轮廓，并将它们与标准的全NA光注入进行比较，可以看出这一点。为了找到实验参数以获得有效的全NA（类似于发射曲线），提取了TF的发射长度和第一发射直径，并与理想的大体积发射器进行了比较。振镜和共振扫描仪方法均显示出与标准Full NA注射液的参考值良好的一致性，从而使神经科学家可以使用单个光学装置从定点照明切换到大体积照明。

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