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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >A System Theoretic Investigation of Cortisol Dysregulation in Fibromyalgia Patients with Chronic Fatigue
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A System Theoretic Investigation of Cortisol Dysregulation in Fibromyalgia Patients with Chronic Fatigue

机译：慢性肌纤维痛患者皮质醇调节异常的系统理论研究

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Fibromyalgia Syndrome (FMS) and Chronic Fatigue Syndrome (CFS) are complex medical conditions with similar symptoms such as anxiety, fatigue, depression, headaches, muscle aches and joint pain. The etiology of both these syndromes is unknown. The objective of this study is to characterize FMS, both in the presence and in the absence of CFS, by analyzing variations in cortisol secretion patterns, timings, amplitudes, and the number of the underlying pulses as well as infusion and clearance rates. The comparison is performed against matched healthy control subjects. We estimate the hormonal secretory events by deconvolving cortisol data using a two-step coordinate descent approach. The first step implements a sparse recovery approach to infer the amplitudes and the timings of the cortisol secretion events from limited cortisol hormone data. The main advantage of this method is estimating the cortisol secretory events using a system theoretic approach. The second step is to estimate the physiological system parameters (i.e. infusion and clearance rates). This approach has been verified on healthy individuals previously. Our results show that the clearance rate of cortisol by the liver is relatively lower in patients as compared to the matched healthy individuals. This suggests that there is a relatively higher accumulation of serum cortisol in patients when compared to matched healthy subjects.
机译：纤维肌痛综合征（FMS）和慢性疲劳综合征（CFS）是复杂的医学疾病，具有类似的症状，例如焦虑，疲劳，抑郁，头痛，肌肉酸痛和关节痛。这两种综合征的病因尚不清楚。这项研究的目的是通过分析皮质醇分泌模式，时间，幅度和潜在脉冲数以及输注和清除率的变化，在有或没有CFS的情况下表征FMS。针对匹配的健康对照受试者进行比较。我们通过使用两步坐标下降法对皮质醇数据进行反卷积来估算激素分泌事件。第一步是实施稀疏恢复方法，以从有限的皮质醇激素数据中推断出皮质醇分泌事件的幅度和时间。该方法的主要优点是使用系统理论方法估算皮质醇分泌事件。第二步是估计生理系统参数（即输注和清除率）。先前已在健康个体上验证了此方法。我们的结果表明，与匹配的健康个体相比，患者对肝脏皮质醇的清除率相对较低。这表明与匹配的健康受试者相比，患者的血清皮质醇蓄积相对较高。

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