High Throughput Screening of Random Heteropolymers that Stabilize Enzymes

机译：高通量筛选可稳定酶的无规杂聚物

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We have tested 180 polymers with varied chain length, composition, charge and structure. These initial studies show promising signs that quickly varying the characteristics of polymers helps identify compositional patterns that lead to stable enzyme formulations. Our next set of experiments will be to characterize these polymers and understand the mechanism through which they stabilize GOx in more relevant conditions. Then, we will apply this approach to other valuable enzymes in need of advanced formulation.

机译：我们已经测试了180种具有不同链长，组成，电荷和结构的聚合物。这些初步研究显示出令人鼓舞的迹象，即迅速改变聚合物的特性有助于鉴定导致稳定酶制剂的组成模式。我们的下一组实验将表征这些聚合物，并了解它们在更相关的条件下稳定GOx的机理。然后，我们将把这种方法应用于需要先进配方的其他有价值的酶。

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《Society for Biomaterials annual meeting and exposition》|2019年|199-199|共1页
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Shashank Kosuri; Matthew Tamasi; Adam J. Gormley;
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4. High Throughput Screening of Random Heteropolymers that Stabilize Enzymes [C] . Shashank Kosuri, Matthew Tamasi, Adam J. Gormley Society for Biomaterials annual meeting and exposition . 2019

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High Throughput Screening of Random Heteropolymers that Stabilize Enzymes

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