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首页> 外文会议>Society for Biomaterials annual meeting and exposition >Fabrication of Nanofibrous Composite Meshes Incorporating Mg metal particles for Nerve Repair Applications
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Fabrication of Nanofibrous Composite Meshes Incorporating Mg metal particles for Nerve Repair Applications

机译：含镁金属颗粒的神经纤维复合纳米网的制备

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摘要

PCL based nanofiber meshes containing embedded Mg metal particles were successfully prepared by electrospinning. The meshes with Mg showed good morphological uniformity and structural integrity, release of Mg~(2+) in physiological solutions, no cytotoxicity in vitro and were well tolerated when implanted in vivo. In vivo, implanted Mg metal containing meshes supported phenomena that suggested increased repair and more rapid tissue healing, suggesting that the Mg mitigated the foreign body responses to PCL. Thus, metal containing composite nanofiber meshes have promise for improving tissue healing in peripheral nerve and other soft tissue repair applications.
机译：通过静电纺丝成功地制备了包含嵌入的Mg金属颗粒的PCL基纳米纤维网。含Mg的网片具有良好的形态均匀性和结构完整性，在生理溶液中释放出Mg〜（2+），在体外无细胞毒性，并且在体内植入时具有良好的耐受性。在体内，植入的含Mg金属的网状物支持现象，表明修复作用增强，组织恢复更快，这表明Mg减轻了异物对PCL的反应。因此，含金属的复合纳米纤维网有望改善周围神经和其他软组织修复应用中的组织愈合。

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