Additive manufacturing of poly(methyl methacrylate) space maintainers for improved craniofacial repair

机译：聚甲基丙烯酸甲酯空间保持剂的增材制造，以改善颅面修复

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Developing this resin is the first step in studying the structure-function relationships determining optimized drug release kinetics and tissue integration of PMMA implants via 3D-printed geometry. Core precursor resin components were formulated from the same raw materials that make up clinical bone cement to increase potential for expedited scale-up and translation. Compound leachability studies will be conducted according to guidance from previous studies that have characterized similar release from porous PMMA space maintainers.7 Also, other future studies will be conducted that pursue adding antibiotic capability to this polymer through the use of a previously developed, drug-loaded thermo-gelling material.3 These studies will use well-defined, low-variance porosity values to elucidate any effects on drug release kinetics, informing later investigations on these 3D-printed constructs' potential to function in their desired antibacterial and scar-prevention capacities.

机译：开发这种树脂是研究通过3D打印的几何结构确定PMMA植入物的最佳药物释放动力学和组织整合的结构与功能关系的第一步。核心前体树脂成分由构成临床骨水泥的相同原料配制而成，以增加快速放大和翻译的潜力。化合物的浸出性研究将根据先前研究的指导进行，这些研究的特征是从多孔PMMA空间保持剂中释放出类似物质。7此外，还将进行其他未来研究，力求通过使用先前开发的药物- 3这些研究将使用定义明确的低方差孔隙率值来阐明对药物释放动力学的任何影响，从而为以后对这些3D打印结构在其所需的抗菌和预防疤痕中的功能潜力的研究提供参考能力。

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《Society for Biomaterials annual meeting and exposition》|2019年|152-152|共1页
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Matthew L. Bedell; Anthony J. Melchiorri; Antonios G. Mikos;
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1. Structural nanospace feature and substrate contribution to maintaining stable porosity of polymer chain in layer-by-layer assembled isotactic poly(methyl methacrylate) films [J] . Ajiro H., Hongo C., Maegawa M., Macromolecules . 2012,第18期

机译：结构纳米空间特征和基质对维持层状组装等规聚甲基丙烯酸甲酯薄膜中聚合物链的稳定孔隙率的贡献
2. Accelerated synthesis of poly(methyl methacrylate)-b-poly(vinyl chloride)-b-poly(methyl methacrylate) block copolymers by the CuCl/tris(2-dimethylaminoethyl)amine-catalyzed living radical block copolymerization of methyl methacrylate initiated with a [J] . Percec V, Guliashvili T, Popov AV, Journal of Polymer Science, Part A. Polymer Chemistry . 2005,第8期

机译：CuCl /三（2-二甲基氨基乙基）胺催化的甲基丙烯酸甲酯的活泼自由基嵌段共聚反应可加速合成聚（甲基丙烯酸甲酯）-b-聚氯乙烯-b-聚甲基丙烯酸甲酯嵌段共聚物
3. Ultrafast synthesis of poly(methyl methacrylate)-b-poly(vinyl chloride)-b- poly(methyl methacrylate) block copolymers by the Cu(0)/tris(2-dimethylaminoethyl)amine-catalyzed living radical block copolymerization of methyl methacrylate initiated with a [J] . Percec V, Guliashvili T, Popov AV, Journal of Polymer Science, Part A. Polymer Chemistry . 2005,第8期

机译：通过Cu（0）/三（2-二甲基氨基乙基）胺催化的甲基丙烯酸甲酯引发的活性自由基嵌段共聚反应超快合成聚甲基丙烯酸甲酯-b-氯乙烯-甲基丙烯酸甲酯嵌段共聚物与
4. Additive manufacturing of poly(methyl methacrylate) space maintainers for improved craniofacial repair [C] . Matthew L. Bedell, Anthony J. Melchiorri, Antonios G. Mikos Society for Biomaterials annual meeting and exposition . 2019

机译：聚（甲基丙烯酸甲酯）空间维护者的添加剂制造，用于改善颅面修复
5. Two Stage Repair of Composite Craniofacial Defects with Antibiotic Releasing Porous Poly(methyl methacrylate) Space Maintainers and Bone Regeneration. [D] . Spicer, Patrick. 2013

机译：抗生素释放多孔聚甲基丙烯酸甲酯空间保持剂和骨再生的复合颅面缺损两阶段修复。
6. Sustaining Antibiotic Release from a Poly(methyl methacrylate)Bone-Spacer [O] . Pongpat Oungeun, Rojrit Rojanathanes, Piya Pinsornsak, 2019

机译：维持聚甲基丙烯酸甲酯的抗生素释放骨垫片
7. Two Stage Repair of Composite Craniofacial Defects with Antibiotic Releasing Porous Poly(methyl methacrylate) Space Maintainers and Bone Regeneration [O] . Spicer Patrick 2013

机译：抗生素释放多孔聚（甲基丙烯酸甲酯）空间保持剂和骨再生两阶段修复颅面缺损。
8. Nuclear Magnetic Resonance Studies of Ionomers. 5. Spectra of Poly(Methyl Methacrylate-co-4-Vinyl Pyridine), Poly(Methyl Methacrylate-co-2-Methyl-5-Vinyl Pyridine), and Their Quaternized Derivatives [R] . Natansohn, A., Eisenberg, A. 1987

机译：离子聚合物的核磁共振研究。 5.聚（甲基丙烯酸甲酯 - 共-4-乙烯基吡啶甲基），聚（甲基丙烯酸甲酯 - 共聚-2-甲基-5-乙烯基吡啶）及其季铵化衍生物的光谱

Additive manufacturing of poly(methyl methacrylate) space maintainers for improved craniofacial repair

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