Shear-thinning bioink with the ability to sequester and release therapeutic proteins from 3D printed structure have been introduced. The bioink consist of degradable PEG-DTT and 2D nanosilicates. The mechanical properties, swelling kinetics, and degradation rate can be modulated via the amount of PEG-DA and nanosilicates. Using the cation exchange capacity of nanosilicates, growth factors were sequestered and released from the 3D printed structure. The activity of released protein therapeutics from 3D structure were verified via migration of cells. Overall, this study provides proof of principle to print therapeutics in 3D that can be used to control and direct cell functions.
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