Ti with a chessboard-patterned surface with nano topography was fabricated by femtosecond laser irradiation. A high orientated cellular morphology showed by cells on Ti surface with patterned topography. Notably, compared with mirror surface, cells cultured on the periodic nano-ripples topography showed a larger calcified area, which indicated superior osteoconductivity. This chessboard-patterned surface nano topography fabricated by femtosecond laser is expected to provide a basis for designing novel biomaterial-cell interfaces to promote the osteoconductivity of medical and dental implants.
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