Nascent protein secretion directs cell mechanosensing and function in three-dimensional hydrogels

机译：新生的蛋白质分泌指导三维水凝胶中的细胞机械传感和功能

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Metabolic labeling with AHA enabled the visualization of nascent proteins and their impact on spreading and mechanosensing of encapsulated cells. Our results indicate that cellular functions in synthetic hydrogels are not only influenced by the initial engineered interface presented to the cell, but also by the deposition and adhesion to nascent ECM proteins. Ongoing work is to better understand these cell-nascent protein interactions and utility for tissue engineering and repair.

机译：使用AHA进行代谢标记可以可视化新生蛋白质及其对封装细胞的扩散和机械传感的影响。我们的结果表明，合成水凝胶的细胞功能不仅受呈递给细胞的初始工程界面的影响，还受到新生ECM蛋白的沉积和粘附的影响。正在进行的工作是更好地了解这些细胞新生蛋白的相互作用以及对组织工程和修复的实用性。

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《Society for Biomaterials annual meeting and exposition》|2019年|359-359|共1页
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Claudia Loebel; Robert L. Mauck; Jason A. Burdick;
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1. Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels [J] . Loebel Claudia, Mauck Robert L., Burdick Jason A. Nature Materials . 2019,第8期

机译：局部新生蛋白质的沉积和重塑指导三维水凝胶中的间质基质细胞的机械传感和命运
2. Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels [J] . Loebel Claudia, Mauck Robert L., Burdick Jason A. Nature Materials . 2019,第8期

机译：局部新生蛋白质沉积和重塑导孔间充质基质电池机械损伤和命运在三维水凝胶中
3. High density lipoprotein promotes nascent apolipoprotein A-V secretion from mRNA transfected cells [J] . Irina Romenskaia, Christine M. DeAntonis, Vladimir Presnyak, Biochemical and Biophysical Research Communications . 2019,第2期

机译：高密度脂蛋白从mRNA转染细胞促进新生载脂蛋白A-V分泌物
4. Nascent protein secretion directs cell mechanosensing and function in three-dimensional hydrogels [C] . Claudia Loebel, Robert L. Mauck, Jason A. Burdick Society for Biomaterials annual meeting and exposition . 2019

机译：新生蛋白质分泌指示三维水凝胶中的细胞机械损伤和功能
5. Phospholipid transfer protein (PLTP): Secretion, gene expression, and functions in cultured cells. [D] . Yuan, Chaoshen. 2001

机译：磷脂转移蛋白（PLTP）：培养细胞的分泌，基因表达和功能。
6. Local nascent protein deposition and remodeling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels [O] . Claudia Loebel, Robert L. Mauck, Jason A. Burdick -1

机译：局部新生蛋白质的沉积和重塑指导三维水凝胶中的间质基质细胞的机械传感和命运
7. Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels [O] . Claudia Loebel, Robert L. Mauck, Jason A. Burdick 2019

机译：局部新生蛋白质沉积和重塑导孔间充质基质电池机械损伤和命运在三维水凝胶中

Nascent protein secretion directs cell mechanosensing and function in three-dimensional hydrogels

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