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Sustained-released platelet-rich plasma from polyethylene glycol hydrogels exerts beneficial effects on chondrocytes

机译:聚乙二醇水凝胶缓释富血小板血浆对软骨细胞产生有益作用

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Taken together, these results indicate that sustained delivery of PRGF is possible through the encapsulation of PRGF in PEG hydrogels. Sustained-released PRGF from PEG hydrogels had a significant beneficial effect on chondrocyte proliferation, as well as a positive effect in the downregulation of catabolic and pro-inflammatory genes (MMP13 and NF Kappa B) in chondrocytes treated with IL-1β, as compared to a bolus PRGF dose or no PRGF treatment.
机译:综上所述,这些结果表明通过将PRGF包封在PEG水凝胶中,PRGF的持续递送是可能的。与用IL-1β处理的软骨细胞相比,从PEG水凝胶中持续释放的PRGF对软骨细胞增殖具有显着的有益作用,并且在下调分解代谢和促炎基因(MMP13和NF Kappa B)方面具有积极作用。推注PRGF剂量或不进行PRGF治疗。

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