Comparison of Human and Porcine Pancreatic Decellularized Extracellular Matrix Bioink using Proteomic Approaches

机译：人和猪胰腺脱细胞细胞外基质生物墨水的蛋白质组学比较

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We demonstrate the validity of porcine derived dECM bioink as an applicable material for 3D bioprinted tissue by analyzing the dECM of the human and pig pancreas treated with the same decellularization process through proteomic approaches. The ratios of constituents and composition of the proteins that organize the pancreatic tissue were explained in detail and the tissue similarity between the human and the pig was verified. The printed tissue using pdECM bioink will be able to broaden the scope of application of not only disease models related to pancreas such as diabetes but also therapeutic transplantable structures with analysis of secreted proteins that play crucial roles in the biological process. Further studies are required to determine the similarity in mechanical cues related to biophysical properties of bioink for the constructive tissue remodeling.

机译：通过分析通过蛋白质组学方法用相同脱细胞过程处理的人和猪胰腺的dECM，我们证明了猪衍生的dECM生物墨水作为3D生物打印组织的适用材料的有效性。详细解释了组成胰腺组织的蛋白质的组成比和组成，并验证了人与猪之间的组织相似性。使用pdECM bioink印刷的组织不仅能够扩大与胰腺相关的疾病模型（例如糖尿病）的应用范围，而且还能通过分析在生物过程中起关键作用的分泌蛋白来扩大治疗性可移植结构的应用范围。需要进一步的研究来确定与用于构造性组织重塑的生物墨水的生物物理特性有关的机械提示的相似性。

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《Society for Biomaterials annual meeting and exposition》|2019年|900-900|共1页
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Myungji Kim; In kyoung Shim; Song Cheol Kim; Jinah Jang;
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2. A mathematical model for analyzing the elasticity, viscosity, and failure of soft tissue: Comparison of native and decellularized porcine cardiac extracellular matrix for tissue engineering [J] . BronshteinT., Au-YeungG.C.T., SarigU., Tissue engineering, Part C. Methods . 2013,第8期

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4. Comparison of Human and Porcine Pancreatic Decellularized Extracellular Matrix Bioink using Proteomic Approaches [C] . Myungji Kim, In kyoung Shim, Song Cheol Kim, Society for Biomaterials annual meeting and exposition . 2019

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5. Extracellular Matrix from Whole Porcine Heart Decellularization for Cardiac Tissue Engineering [D] . Momtahan, Nima 2016

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6. A Mathematical Model for Analyzing the Elasticity Viscosity and Failure of Soft Tissue: Comparison of Native and Decellularized Porcine Cardiac Extracellular Matrix for Tissue Engineering [O] . Tomer Bronshtein, Gigi Chi Ting Au-Yeung, Udi Sarig, -1

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Comparison of Human and Porcine Pancreatic Decellularized Extracellular Matrix Bioink using Proteomic Approaches

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