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A Unified Multi-task Adversarial Learning Framework for Pharmacovigilance Mining

机译:药物警戒挖掘的统一多任务对抗学习框架

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The mining of adverse drug reaction (ADR) has a crucial role in the pharmacovigilance. The traditional ways of identifying ADR are reliable but time-consuming, non-scalable and offer a very limited amount of ADR relevant information. With the unprecedented growth of information sources in the forms of social media texts (Twitter, Blogs, Reviews etc.), biomedical literature, and Electronic Medical Records (EMR), it has become crucial to extract the most pertinent ADR related information from these free-form texts. In this paper, we propose a neural network inspired multitask learning framework that can simultaneously extract ADRs from various sources. We adopt a novel adversarial learning-based approach to learn features across multiple ADR information sources. Unlike the other existing techniques, our approach is capable to extracting fine-grained information (such as 'Indications', 'Symptoms', 'Finding', 'Disease', 'Drug') which provide important cues in pharmacovigilance. We evaluate our proposed approach on three publicly available real-world benchmark pharmacovigilance datasets, a Twitter dataset from PSB 2016 Social Media Shared Task, CADEC corpus and Medline ADR corpus. Experiments show that our unified framework achieves state-of-the-art performance on individual tasks associated with the different benchmark datasets. This establishes the fact that our proposed approach is generic, which enables it to achieve high performance on the diverse datasets. The source code is available here~1.
机译:不良药物反应(ADR)的挖掘在药物警戒中具有至关重要的作用。识别ADR的传统方法可靠但耗时,不可扩展,并且提供的ADR相关信息非常有限。随着社交媒体文本(Twitter,博客,评论等),生物医学文献和电子病历(EMR)形式的信息源的空前增长,从这些免费信息中提取最相关的ADR相关信息已变得至关重要。形式的文本。在本文中,我们提出了一种由神经网络启发的多任务学习框架,该框架可以同时从各种来源提取ADR。我们采用一种新颖的基于对抗学习的方法来跨多个ADR信息源学习功能。与其他现有技术不同,我们的方法能够提取细粒度的信息(例如“适应症”,“症状”,“发现”,“疾病”,“药物”),这些信息可为药物警戒性提供重要线索。我们在三个可公开获得的现实世界基准药物警戒性数据集,来自PSB 2016社交媒体共享任务的Twitter数据集,CADEC语料库和Medline ADR语料库中评估了我们提出的方法。实验表明,我们的统一框架在与不同基准数据集相关联的单个任务上实现了最先进的性能。这证明了我们提出的方法是通用的,这使它能够在各种数据集上实现高性能。源代码在此处可用〜1。

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