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首页> 外文会议>International Conference on Advanced Technologies for Signal and Image Processing >Optimal Parameters of Diffusion MRI measuring Corticospinal Tract Integrity in healthy subjects
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Optimal Parameters of Diffusion MRI measuring Corticospinal Tract Integrity in healthy subjects

机译：扩散MRI测量健康受试者皮质脊髓完整性的最佳参数

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Diffusion weighted imaging (DWI-MRI) is debatably the method of choice for characterizing brain microstructure non-invasively and in vivo in the chronic phase post-stroke. In fact, the degree of motor impairment after stroke is closely linked to the structural integrity of the corticospinal tract (CST). The aim of our study was to extract tract biophysical characteristics such as fractional anisotropy (FA) and Apparent Diffusion Coefficient (ADC) from the CST and to identify the optimal parameters of measuring CST integrity. We conduct experiments with ten healthy human subjects. For each subject, biophysical values were calculated for two Regions of Interest (the posterior limb of the internal capsule and the anterior pons) at two b-value (b=1000s/mm2 and b=3000 s/mm2). In this work, our results showed that the pons region more accurately predict CST integrity than the posterior limb of internal capsule using a b-value equal to 1000 s/mm2. FA and ADC are a promising metric for clinical applications.
机译：扩散加权成像（DWI-MRI）无疑是在卒中后慢性期无创和体内表征脑微结构的首选方法。实际上，中风后运动障碍的程度与皮质脊髓束（CST）的结构完整性紧密相关。我们研究的目的是从CST中提取诸如分数各向异性（FA）和表观扩散系数（ADC）之类的生物物理特性，并确定测量CST完整性的最佳参数。我们对十个健康的人类受试者进行了实验。对于每个受试者，以两个b值（b = 1000s / mm）计算两个目标区域（内囊的后肢和前桥）的生物物理值 2 并且b = 3000 s / mm 2 ）。在这项工作中，我们的研究结果表明，使用等于1000 s / mm的b值，脑桥区域比内囊后肢更准确地预测CST完整性 2 。 FA和ADC是用于临床应用的有前途的指标。

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