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首页> 外文会议>Conference of the European Study Group on Cardiovascular Oscillations >Vascular dysfunction and autonomic failure are associated in a porcine model of septic shock and resuscitation
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Vascular dysfunction and autonomic failure are associated in a porcine model of septic shock and resuscitation

机译：在感染性休克和复苏的猪模型中，血管功能障碍和自主神经功能衰竭相关

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Acute inflammation and sepsis are known to impair endothelial functions and autonomic nervous system (ANS)-based regulatory mechanisms. Our objective is to assess the effectiveness of standard resuscitation at vascular level and to investigate if there is any association between vascular and autonomic alterations. Six pigs underwent to a protocol of polymicrobial septic shock and resuscitation (fluids and noradrenaline). The characteristic arterial time constant $au$ was computed in aorta and in the femoral artery, together with estimates of total arterial compliance and peripheral resistance. Baroreflex sensitivity was computed to assess ANS functionality. Septic shock induced a severe vascular disarray and ANS dysfunction, which resulted correlated. This compromised condition was not resolved by resuscitation. Measures of vascular function and ANS activity may represent useful end-points to guide the resuscitation, in combination with standard hemodynamic and clinical markers.
机译：已知急性炎症和败血症会损害内皮功能和基于自主神经系统（ANS）的调节机制。我们的目标是评估标准复苏在血管水平上的有效性，并调查血管和自主神经改变之间是否存在任何关联。对六只猪进行了多菌性败血性休克和复苏（液体和去甲肾上腺素）的方案。特征动脉时间常数 $ \ tau $ 计算主动脉和股动脉的总动脉顺应性和周围阻力。计算压力反射敏感性以评估ANS功能。败血性休克引起严重的血管紊乱和ANS功能障碍，这与相关性有关。复苏不能解决这种受损的情况。血管功能和ANS活性的量度可能与标准的血液动力学和临床指标结合起来，代表了指导复苏的有用终点。

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