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Analyzing the Immune Response of Neoepitopes for Personalized Vaccine Design

机译：分析个性化疫苗设计的新表位的免疫反应

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In the last few years, the importance of neoepitopes for the development of personalized antitumor vaccines has increased remarkably. This kind of epitopes are considered to generate a strong immune reaction, while their non-mutated version, which sometimes differs only in a single amino-acid, does not generate a response at all. In order to study if, regardless the immune tolerance, neoepitopes are quantitatively more immunogenic than the original strings, we have obtained samples of mutated and non-mutated epitopes of six patients with cutaneous melanoma in different stages, and then we have compared them. More precisely, we have used several bioinformatic tools to study certain properties of the epitopes such as the HLA binding affinity of classes I and II, and found that some of them are in fact increased in their mutated versions, which supports the hypothesis, and also reinforces the use of neoepitopes for cancer vaccine design.
机译：在最近几年中，新表位对于开发个性化抗肿瘤疫苗的重要性显着增加。这种表位被认为会产生强烈的免疫反应，而它们的非突变形式有时仅在单个氨基酸上有所不同，根本不会产生应答。为了研究，不管免疫耐受性如何，新表位在数量上都比原始字符串更具免疫原性，我们获得了六个不同阶段皮肤黑素瘤患者的突变表位和非突变表位样本，然后进行了比较。更确切地说，我们使用了多种生物信息学工具来研究表位的某些特性，例如I类和II类的HLA结合亲和力，发现其中一些实际上在其突变形式上有所增加，这支持了这一假设，并且加强了新表位在癌症疫苗设计中的使用。

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