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Full-size anthropomorphic phantom for 2D and 3D breast x-ray imaging

机译:用于2D和3D乳腺X射线成像的全尺寸拟人幻像

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Anthropomorphic breast phantoms are used to create images that mimic aspects of clinical breast images and are useful in optimization and characterization of breast imaging systems. Here, a full-sized compressed physical breast phantom is designed and manufactured with 100 μm resolution, high reproducibility and x-ray properties similar to that of breast tissues. The phantom design is based on a digital model derived from the morphology and distribution of large, medium and small scale fibroglandular and inter-glandular adipose tissue observed in clinical breast computerized tomography (bCT) images. The physical phantom consists of four slabs of a polyamide-12 component that mimics adipose tissue fabricated using selective laser sintering (SLS). The fibroglandular component is a low viscosity resin doped with a small amount of zinc oxide nanoparticles (<110 nm) to increase attenuation. The phantom was imaged on a Senographe Pristina and compared to image simulations of the virtual phantom. The power spectral parameter, β was 3.8±0.2 and 3.9±0.5 for the physical and virtual phantoms in a digital mammogram. The corresponding Laplacian fractional entropy (LFE) averaged 0.22 and 0.14 across the range 0.125-1.29 mm~(-1). Very good texture cancellation was obtained in contrast-enhanced spectral mammography.
机译:拟人化的乳房幻影用于创建模仿临床乳房图像各个方面的图像,可用于乳房成像系统的优化和表征。在这里,设计并制造了具有100μm分辨率,与乳房组织相似的高重现性和X射线特性的全尺寸压缩物理乳房幻像。幻像设计基于数字模型,该数字模型源自在临床乳腺计算机断层摄影(bCT)图像中观察到的大,中,小比例纤维腺和腺间脂肪组织的形态和分布。物理模型由四个聚酰胺12组件的平板组成,这些平板模仿使用选择性激光烧结(SLS)制成的脂肪组织。纤维腺成分是掺有少量氧化锌纳米颗粒(<110 nm)以增加衰减的低粘度树脂。该体模在Senographe Pristina上成像,并与虚拟体模的图像模拟进行比较。对于数字乳房X光照片中的物理和虚拟体模,功率谱参数β为3.8±0.2和3.9±0.5。相应的拉普拉斯分数熵(LFE)在0.125-1.29 mm〜(-1)范围内平均为0.22和0.14。在对比度增强的乳腺X线摄影中获得了非常好的纹理消除。

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