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Calculation of Radiomic Features to Validate the Textural Realism of Physical Anthropomorphic Phantoms for Digital Mammography

机译:放射学特征的计算,以验证数字化乳腺摄影的物理拟人化幻影的纹理真实感

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In this paper, radiomic features are used to validate the textural realism of two anthropomorphic phantoms for digital mammography. One phantom was based off a computational breast model; it was 3D printed by CIRS (Computerized Imaging Reference Systems. Inc., Norfolk, VA) under license from the University of Pennsylvania. We investigate how the textural realism of this phantom compares against a phantom derived from an actual patient's mammogram ("Rachel", Gammex 169, Madison, WI). Images of each phantom were acquired at three kV in 1 kV increments using auto-time technique settings. Acquisitions at each technique setting were repeated twice, resulting in six images per phantom. In the raw ("FOR PROCESSING") images, 341 features were calculated; i.e.. gray-level histogram, co-occurrence, run length, fractal dimension, Gabor Wavelet, local binary pattern, Laws, and co-occurrence Laws features. Features were also calculated in a negative screening population. For each feature, the middle 95% of the clinical distribution was used to evaluate the textural realism of each phantom. A feature was considered realistic if all six measurements in the phantom were within the middle 95% of the clinical distribution. Otherwise, a feature was considered unrealistic. More features were actually found to be realistic by this definition in the CIRS phantom (305 out of 341 features or 89.44%) than in the phantom derived from a specific patient's mammogram (261 out of 341 features or 76.54%). We conclude that the texture is realistic overall in both phantoms.
机译:在本文中,放射学特征被用于验证数字化乳腺摄影的两个拟人化体模的纹理真实性。一个幻影是基于计算乳房模型的;在宾夕法尼亚大学的许可下,它是由CIRS(计算机成像参考系统公司,弗吉尼亚州诺福克)进行3D打印的。我们调查了该体模的真实感如何与从实际患者的乳房X线照片(“ Rachel”,Gammex 169,麦迪逊,威斯康星州)得出的体模进行比较。使用自动时间技术设置,以3 kV以1 kV的增量获取每个体模的图像。每个技术设置下的采集重复两次,每个幻像产生六张图像。在原始(“用于处理”)图像中,计算了341个特征;即灰度直方图,共现,游程长度,分形维数,Gabor小波,局部二进制模式,定律和共现定律特征。在阴性筛查人群中也计算特征。对于每个特征,中间95%的临床分布用于评估每个体模的纹理真实感。如果幻象中的所有六个测量值均在临床分布的中间95%以内,则该功能被认为是现实的。否则,该功能被认为是不现实的。实际上,通过此定义,在CIRS体模中发现的特征比在特定患者的乳房X线照片中产生的特征(在341个特征中占261个,占76.54%)更现实(在341个特征中占305个,占89.44%)。我们得出结论,两个幻影的纹理总体上都是逼真的。

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