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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Reducing tachycardia in septic shock patients: do esmolol and ivabradine have a chronotropic effect only?
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Reducing tachycardia in septic shock patients: do esmolol and ivabradine have a chronotropic effect only?

机译：减少败血性休克患者的心动过速：艾司洛尔和伊伐布雷定是否仅具有变时作用？

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摘要

An elevated heart rate (HR) often persists in resuscitated septic shock patients, increasing the risk of mortality. Several drugs for HR control, such as esmolol and ivabradine, have been tested in the recent years, but their benefit on the overall cardiovascular system is still under investigation. The aim of this study is to investigate the hemodynamic effects of the two drugs in a protocol of polymicrobial septic shock and resuscitation, mainly focusing on the vascular function. Twelve pigs were divided into three experimental groups: the esmolol-treated group (n=4), the ivabradine-treated group (n=5) and the control group (n=3). The characteristic arterial time constant τ was computed on aortic arterial pressure (AoP), together with estimates of total arterial compliance and peripheral resistance. Power spectral analysis of aortic and radial diastolic BP oscillations was performed to estimate the sympathetic autonomic control of vascular tone. Septic shock induced a severe cardiac and vascular disarray, only partially resolved by resuscitation. The administration of esmolol, but not ivabradine, was beneficial both for cardiac and vascular function, thereby its adjunction to standard therapies could help to improve patient’s condition and optimize the resuscitation strategies.Clinical Relevance-This study shows a potential beneficial effect of esmolol on the arterial tree
机译：在复苏的败血性休克患者中经常会出现心率（HR）升高的情况，从而增加了死亡风险。近年来已经测试了几种用于控制HR的药物，例如艾司洛尔和伊伐布雷定，但它们对整体心血管系统的益处仍在研究中。这项研究的目的是研究两种药物在微生物败血症性休克和复苏方案中对血液动力学的影响，主要集中在血管功能上。将十二只猪分为三个实验组：艾司洛尔治疗组（n = 4），伊伐布雷定治疗组（n = 5）和对照组（n = 3）。在主动脉压力（AoP）上计算特征性动脉时间常数τ，并估算总动脉顺应性和周围阻力。进行主动脉和径向舒张压BP振荡的功率谱分析，以评估交感神经自主控制血管紧张度。败血性休克引起严重的心脏和血管紊乱，只有通过复苏才能部分解决。艾司洛尔而非伊伐布雷定对心脏和血管功能均有益，因此将其与标准疗法配合使用可帮助改善患者的病情并优化复苏策略。动脉树

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