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首页> 外文会议>Photochemotherapy: Photodynamic Therapy and Other Modalities >Chemical induction of skin tumors in hairless (Skh-1) mice in view of photochemotherapy
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Chemical induction of skin tumors in hairless (Skh-1) mice in view of photochemotherapy

机译：鉴于光化学疗法，化学治疗无毛（Skh-1）小鼠的皮肤肿瘤

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Abstract: The effects of a classic two-stage carcinogenesis protocol on the formation of skin tumors in hairless female SKH-1 mice were studied in order to carry out photochemotherapy on the mice bearing tumors later. Mice were initiated with a single application of 100 nmol of 7,12- dimethylbenz$LB@a$RB@anthracene in 0.1 ml acetone and promoted one week later, twice weekly with topical applications of 1.8 nmol (first protocol) or 5 nmol (second protocol) 12-o- tetradecanoylphorbol-13-acetate in 0.1 ml acetone. The first tumors occurred between 4 and 6 weeks after the beginning of the promotion process depending on the protocol and the percentage of mice bearing tumors increased and reached 41% and 100% at the end of the treatment respectively for the first and the second protocol. Depending on the protocol, the tumor yield was 0.8 for the first one and approximately 10 for the second one whereas we expected 3 tumors per mouse. Histology of some skin tumors revealed that all were papillomas, hence benign tumors. These papillomatous lesions seem characteristic of a viral attack as seen in other strains of mammals including humans. !21
机译：摘要：研究了经典的两阶段致癌方案对无毛雌性SKH-1小鼠皮肤肿瘤形成的影响，以便随后对患有肿瘤的小鼠进行光化学疗法。通过在0.1 ml丙酮中单次施用100 nmol的7,12-二甲基苯并$ LB @ a $ RB @蒽来引发小鼠，并于一周后，每周两次局部应用1.8 nmol（第一方案）或5 nmol（第二方案）在0.1 ml丙酮中的12-邻-十四烷酰基佛波醇13-乙酸酯。最初的肿瘤发生在促进过程开始后的4到6周之间，具体取决于治疗方案，并且携带肿瘤的小鼠的百分比增加，并且在治疗结束时对于第一和第二种治疗方案分别达到41％和100％。根据方案，第一个小鼠的肿瘤产量为0.8，第二个肿瘤的肿瘤产量约为10，而我们预计每只小鼠3个肿瘤。一些皮肤肿瘤的组织学显示所有都是乳头状瘤，因此是良性肿瘤。如在包括人在内的其他哺乳动物品系中所见，这些乳头状病变似乎是病毒攻击的特征。 ！21

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