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首页> 外文会议>Photochemotherapy: Photodynamic Therapy and Other Modalities II >Multi-course PDT of malignant tumors: the influence on primary tumor metastatic spreading and homeostasis of cancer patients
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Multi-course PDT of malignant tumors: the influence on primary tumor metastatic spreading and homeostasis of cancer patients

机译：恶性肿瘤的多疗程PDT：对癌症患者原发性肿瘤转移扩散和体内稳态的影响

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Abstract: The first clinical trials of photodynamic therapy (PDT) of cancer with two photosensitizers, PHOTOHEME and PHOTOSENS, were started in P.A. Hertzen Research Oncological Institute (Moscow, Russia) in 1992 and 1994. Up to now, 208 patients with primary, recurrent and metastatic malignant tumors (469) of skin (34 patients/185 tumors), breast cancer (24/101), head and neck (30/31), trachea and bronchus (31/42), esophagus (35/35), stomach (31/32), rectum (4/4), vagina and uterine cervix (7/8) and bladder (12/31) have been treated by PDT. One-hundred-thirty patients were injected with PHOTOHEME, 64 patients were injected with PHOTOSENS, 14 patients were injected with PHOTOHEME and PHOTOSENS. Totally, 302 courses of treatment were performed: 155 patients had one course and 53 patients were subjected to two to nine PDT sources with intervals from 1 to 18 months. A therapeutic effect of a one-course and multi- course PDT of malignant tumors (respiratory, digestive and urogenital systems) was evaluated clinically, histologically, roentgenologically, sonographically and endoscopically. The biochemical, hematological and immunological investigations were performed for all the patients in dynamics. Results of our study showed that a multi-course PDT method seems to be perspective in treatment of malignant tumors of basic localizations. !18
机译：【摘要】两种光敏剂PHOTOHEME和PHOTOSENS对癌症进行光动力疗法（PDT）的临床试验已在宾夕法尼亚州启动。 Hertzen Research Oncological Institute（俄罗斯莫斯科），分别于1992年和1994年。到目前为止，有208例皮肤原发性，复发性和转移性恶性肿瘤（469例）（34例患者/ 185例），乳腺癌（24/101例），头部和颈部（30/31），气管和支气管（31/42），食道（35/35），胃（31/32），直肠（4/4），阴道和子宫颈（7/8）和膀胱（ 12/31）已由PDT处理。一百三十三名患者注射了苯丙氨酸甲酯，六十四名患者被注射了磷酸盐，十四名患者被注射了苯丙氨酸甲酯和苯丙氨酸甲酯。总共进行了302个疗程的治疗：155例患者接受了一个疗程，53例患者接受了2到9个PDT源，间隔时间为1到18个月。从临床，组织学，放射学，超声和内窥镜评估了单疗程和多疗程PDT对恶性肿瘤（呼吸系统，消化系统和泌尿生殖系统）的治疗效果。对所有患者进行了生化，血液学和免疫学研究。我们的研究结果表明，多过程PDT方法似乎是治疗基本定位的恶性肿瘤的一种方法。 ！18

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