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首页> 外文会议>Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE >Microfabricated device for arterial wall and atherosclerotic plaque penetration
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Microfabricated device for arterial wall and atherosclerotic plaque penetration

机译：动脉壁和动脉粥样硬化斑块穿透的超细装置

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Percutaneous coronary intervention is currently used to treat coronary atherosclerosis but is plagued by restenosis. The atherosclerotic plaque acts as a barrier, preventing the delivery of drugs or gene therapy to prevent restenosis. The authors hypothesize that microfabricated probes, manufactured using silicon fabrication technology, can penetrate through atherosclerotic plaque, creating paths for therapeutic delivery. Two sets of microfabricated probes (65/spl plusmn/15 and 140/spl plusmn/20 /spl mu/m) were deployed in normal and atherosclerotic rabbit iliac artery segments (n=5 each) under distention pressures of 100, 200, 300, and 500 mmHg, to simulate deployed stents. The tissues were fixed while the probes remained in place and analyzed using standard SEM, TEM and light microscopy techniques to evaluate the extent and nature of vessel penetration. In healthy tissue, microprobes are able to pierce the internal elastic lamina and penetrate the media, with the highest probes nearly reaching the media/adventitia boundary. Atherosclerotic plaque is pierced by microprobes at all intraluminal pressures examined. These results indicate that microprobes may serve as a technique to penetrate the atherosclerotic plaque for the purpose of delivering therapeutics beyond the plaque.
机译：经皮冠状动脉介入治疗目前用于治疗冠状动脉粥样硬化，但再狭窄受到困扰。动脉粥样硬化斑块起着屏障的作用，阻止了药物的输送或基因疗法的预防，以防止再狭窄。作者假设使用硅制造技术制造的微型探针可以穿透动脉粥样硬化斑块，从而为治疗提供了途径。在100、200、300的扩张压力下，将两组微型探针（65 / spl plusmn / 15和140 / spl plusmn / 20 / spl mu / m）部署在正常和动脉粥样硬化兔动脉段（每个n = 5）中和500 mmHg，以模拟展开的支架。固定探针的同时将组织固定，并使用标准SEM，TEM和光学显微镜技术进行分析，以评估血管穿透的程度和性质。在健康组织中，微探针能够刺穿内部弹性层并穿透培养基，其中最高的探针几乎到达培养基/外膜边界。在所有检查的腔内压力下，微探针刺穿动脉粥样硬化斑块。这些结果表明，微探针可以用作穿透动脉粥样硬化斑块的技术，以将治疗剂递送到斑块之外。

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