首页> 外文会议>1995 IEEE engineering in medicine and biology 17th annual conference and 21st Canadian medical and biological engineering conference >Power spectral analysis of arterial blood pressure in mice: comparison between normal and endothelin-1 gene knocked out mice
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Power spectral analysis of arterial blood pressure in mice: comparison between normal and endothelin-1 gene knocked out mice

机译:小鼠动脉血压的功率谱分析:正常和内皮素-1基因敲除小鼠的比较

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In mice heterozygous for endothelin-1 gene mutation and wild-type littermates power spectrum of systolic arterial pressure (SAP) was determined in a conscious state by forward-backward autoregressive model with maximum entropy method. It was composed of low (LF) and high frequency components (HF). LF reflected sympathetic vasoconstrictor activity, whereas HF was inversely related to respiratory movement. In ET-1 heterozygous mice LF and HF were both significantly elevated than in wild-type mice. We conclude that power spectral analysis is a useful mathematical tool to study the autonomic cardiovascular control and respiration in mice and that sympathetic vasoconstrictor activity was increased in ET-1 heterozygous mice. The latter finding may account for observed elevation of arterial pressure (AP) in these mutant mice.
机译:在小鼠内皮蛋白-1基因突变和野生型凋落物中,通过最大熵方法以有意识状态测定收缩系统动脉压(SAP)的野生型凋落物功率谱。它由低(LF)和高频分量(HF)组成。 LF反映了交感神经血管收缩剂的活动,而HF与呼吸运动相反。在ET-1中,杂合小鼠LF和HF均比野生型小鼠显着升高。我们得出结论,功率谱分析是一种有用的数学工具,用于研究小鼠的自主神经血管控制和呼吸,并且在ET-1杂合小鼠中增加了同情的血管收缩剂活性。后一种发现可能考虑观察到这些突变小鼠中的动脉压(AP)的升高。

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