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首页> 外文会议>Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE >Cytocompatibility of new-type sulfonated polymer surfaces
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Cytocompatibility of new-type sulfonated polymer surfaces

机译：新型磺化聚合物表面的细胞相容性

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Human umbilical vein endothelial cells (HUVEC) are chosen to test the cytocompatibility of the modified polymer surfaces and study the cell-material surface interaction with an attempt to develop new-type biofunctional polymer surfaces. A new-type sulphonated polymer surface has been prepared by a solution technique and the sulfonated polymer surface obtained has shown a good antithrombogenic property by in vitro clotting time evaluation and platelet adhesion experiments. Sulfonated SPEO is obtained by the reaction of stearic polyethylene oxide (SPEO) and 1,3-propane sulfone. Polystyrene (PS) is used as model polymer. The sulfonated polymer surfaces (SS surfaces) are obtained by the sulfonated SPEO (SSPEO) THF/water solution treatment. The modified PS surfaces are characterized by SEM and ESCA. The EC adhesion and proliferation experiments are done on the modified surfaces by red cell counting, and the morphology of the adhered ECs is observed by SEM. The results show that SS surfaces are of good cytocompatibility. The reason is attributed to the combined influence of functional groups SO/sub 3//sup -/ and flexible PEO chains.
机译：选择人脐静脉内皮细胞（HUVEC）来测试修饰的聚合物表面的细胞相容性，并研究细胞-材料表面的相互作用，以尝试开发新型的生物功能聚合物表面。通过溶液技术制备了新型的磺化聚合物表面，并且通过体外凝结时间评估和血小板粘附实验，所获得的磺化聚合物表面显示出良好的抗血栓形成性能。磺化的SPEO是通过硬脂聚环氧乙烷（SPEO）与1,3-丙烷砜反应制得的。聚苯乙烯（PS）用作模型聚合物。通过磺化SPEO（SSPEO）THF /水溶液处理获得磺化的聚合物表面（SS表面）。改性的PS表面通过SEM和ESCA表征。通过红细胞计数在修饰的表面上进行EC粘附和增殖实验，并通过SEM观察粘附的EC的形态。结果表明SS表面具有良好的细胞相容性。原因归因于官能团SO / sub 3 // sup-/和柔性PEO链的综合影响。

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