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首页> 外文会议>Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE >Noninvasive measurement of left ventricular contractility using gated myocardial SPECT and arterial pressure tonometer
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Noninvasive measurement of left ventricular contractility using gated myocardial SPECT and arterial pressure tonometer

机译：门控心肌SPECT和动脉压眼压计的无创测量左心室收缩力

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For the estimation of left ventricular (LV) contractility, the fully noninvasive measurement of the maximum elastance (E/sub max/) from the steady-state single loop of end systolic pressure volume relation (ESPVR) is attempted. For 32 patients with coronary artery disease, we performed the gated myocardial SPECT with the simultaneous measurement of radial artery pressure using automated tonometer. The left ventricular volume generated from quantitative gated SPECT (QGS) program of SPECT and the central aortic pressure transferred from radial artery pressure measured by automated tonometer were used to make a pressure-volume (PV) loop. With a single PV loop, E/sub max/, was calculated using (1) single PV loop estimation method based on the consistency of normalized elastance curve and (2) regression method based on time-linearity of elastance, respectively. The values of E/sub max/ by the first method were distributed within the range (2.3-5.3) and showed the independence on calculation trials and initial condition for iterative calculation. Normalized elastance curves were consistent for all patients. The E/sub max/ and V/sub 0/ for PV data from sequential gated SPECT acquisition showed the consistent value, respectively (r=0.91 for E/sub max/, r=0.99 for V/sub 0/). The values of E/sub max/ by the second method were within (0.7-5.1) and showed the linear relationship (E/sub max normalized/=2.15/spl times/E/sub max linear/+0.45, r=0.64, p>0.001) with E/sub max/ by the first method. Despite of the lack of comparison with multiple PV loop method, we found the clinical feasibility of this fully noninvasive E/sub max/, estimation method. Therefore, we concluded that E/sub max/ obtained by this methods could be useful for assessment of LV contractility.
机译：为了评估左心室（LV）的收缩力，尝试从末梢收缩压容积关系的稳态单环（ESPVR）进行最大无弹性（E / sub max /）的完全无创测量。对于32例冠状动脉疾病患者，我们进行了门控心肌SPECT，同时使用自动眼压计同时测量radial动脉压力。通过SPECT定量门控SPECT（QGS）程序生成的左心室容积和由自动眼压计测量的从radial动脉压力转移来的中心主动脉压力被用来构成压力容积（PV）回路。对于单个PV回路，分别使用（1）基于归一化弹性曲线的一致性的单个PV回路估计方法和（2）基于弹性时间线性的回归方法来计算E / sub max /。第一种方法的E / sub max /值分布在（2.3-5.3）范围内，并显示了计算试验的独立性和迭代计算的初始条件。所有患者的标准化弹性曲线均一致。来自顺序门控SPECT采集的PV数据的E / sub max /和V / sub 0 /分别显示一致的值（E / sub max / r = 0.91，V / sub 0 / r = 0.99）。第二种方法的E / sub max /值在（0.7-5.1）之内，并且显示出线性关系（E / sub max归一化/=2.15/spl次/ E / sub max线性/+0.45，r=0.64， p> 0.001），第一种方法使用E / sub max /。尽管缺乏与多个PV回路方法的比较，但我们发现了这种完全无创的E / sub max /估算方法的临床可行性。因此，我们得出的结论是，通过这种方法获得的E / sub max /可用于评估LV收缩力。

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