In order to investigate the anatomical variables that affect ventricular defibrillation thresholds (DFTs), Finite Element Thorax models were built from MRI and fast CT images of two patients. One patent had a dilated left ventricle (LV), LV hypertrophy, 30% ejection fraction, and a relatively small RV. The other patient had large cardiac dimensions (upper bound of normal) but no heart disease. The primary defibrillation electrode configurations, i.e. Superior Vena Cava (SVC) to Right Ventricle (RV) (SVC-RV), left pectoral Can to RV (Can-RV) and Can+SVC-RV, were analyzed and compared in the two models. The DFTs were calculated based on 95% ventricular mass with voltage gradient greater than 5 V/cm and these results were also compared with the clinical data. The FEA results show that anatomical variation can affect ventricular DFTs for certain lead configurations. The DFTs with Can+SVC-RV and Can-RV systems are robust and relatively insensitive to these anatomical differences.
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机译：为了研究影响心室除颤阈值（DFT）的解剖学变量，根据两名患者的MRI和快速CT图像建立了有限元胸腔模型。一项专利具有左心室扩张（LV），左室肥大，射血分数30％和相对较小的RV。另一例患者的心脏尺寸较大（正常范围上限），但无心脏病。在两个模型中分析并比较了主要的除颤电极配置，即上腔静脉（SVC）至右心室（RV）（SVC-RV），左胸Can to RV（Can-RV）和Can + SVC-RV 。根据95％的心室质量（电压梯度大于5 V / cm）计算DFT，并将这些结果与临床数据进行比较。 FEA结果表明，对于某些导线配置，解剖结构变化会影响心室DFT。具有Can + SVC-RV和Can-RV系统的DFT坚固且对这些解剖差异不敏感。
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