Effect of the degree of trimethylation of chitosan on the permeability of~(14)c-mannitol through intestinal caco-2 monolayers

机译：壳聚糖三甲基化程度对〜（14）c-甘露糖醇通过肠道caco-2单层渗透性的影响

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Chitosan attracts a lot of interest as an absorption enhancer for the peroral delivery of peptide and protein drugs. Still chitosan's low solubility at intestinal pH values (>7.0) impedes this permeation enhancing effect. Lately a novel chitosan derivative, N-trimethyl chitosan chloride (TMC), has been referred as a potential absorption enhancer of peptide and protein drugs.

机译：壳聚糖作为经肽和蛋白质药物经口递送的吸收促进剂引起了广泛的兴趣。壳聚糖在肠道pH值（> 7.0）时的低溶解性仍然阻碍了这种渗透增强作用。最近，一种新型的壳聚糖衍生物N-三甲基壳聚糖氯化物（TMC）被称为肽和蛋白质药物的潜在吸收促进剂。

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《International symposium on controlled release of bioactive materials;Consumer and diversified products conference》|1998年|p.14-15|共2页
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M. Thanou; A.F. Kotze; A.G. de Boer; J.C. Verhoef; H.E. Junginger;
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中图分类基础医学;
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1. A comparison of the effect of chitosan and chitosan-coated vesicles on monolayer integrity and permeability across Caco-2 and 16HBE14o-cells. [J] . Kudsiova L, Lawrence MJ Journal of pharmaceutical sciences. . 2008,第9期

机译：壳聚糖和壳聚糖囊泡对Caco-2和16HBE14o细胞单层完整性和通透性的影响比较。
2. Effect of aliphatic and aromatic thiolated chitosan conjugates on permeability of ritonavir across caco-2 cell monolayers and rat intestinal membrane [J] . Duangkamon Sakloetsakun, Andreas Bernkop Schnürch Asia-Pacific Journal of Science and Technology . 2012,第3期

机译：脂肪族和芳香族硫醇化壳聚糖共轭物对利托那韦跨caco-2细胞单层和大鼠肠膜通透性的影响
3. Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers [J] . Thanou MM., Scharringhausen T., Luessen HL., Journal of Controlled Release: Official Journal of the Controlled Release Society . 2000,第1a3期

机译：N-三甲基壳聚糖氯化季铵化程度对增强亲水性化合物跨肠Caco-2细胞单层转运的影响
4. Effect of the degree of trimethylation of chitosan on the permeability of~(14)c-mannitol through intestinal caco-2 monolayers [C] . M. Thanou, A.F. Kotze, A.G. de Boer, International symposium on controlled release of bioactive materials . 1998

机译：壳聚糖三甲基化程度对含有肠Caco-2单层〜（14）C-甘露醇渗透性的影响
5. The effect of chitosans and other excipients on the permeation of ketotifen and other drug models through Caco-2 cells. [D] . Sou, Mary. 2004

机译：壳聚糖和其他赋形剂对酮替芬和其他药物模型通过Caco-2细胞渗透的影响。
6. In vitro Permeability Enhancement in Intestinal Epithelial Cells (Caco-2) Monolayer of Water Soluble Quaternary Ammonium Chitosan Derivatives [O] . Jariya Kowapradit, Praneet Opanasopit, Tanasait Ngawhirunpat, 2010

机译：水溶性季铵壳聚糖衍生物在肠上皮细胞（Caco-2）单层中的体外渗透性增强
7. In vitro Permeability Enhancement in Intestinal Epithelial Cells (Caco-2) Monolayer of Water Soluble Quaternary Ammonium Chitosan Derivatives [O] . Kowapradit, Jariya, Opanasopit, Praneet, Ngawhirunpat, Tanasait, 2010

机译：水溶性季铵壳聚糖衍生物在肠上皮细胞（Caco-2）单层中的体外渗透性增强

Effect of the degree of trimethylation of chitosan on the permeability of~(14)c-mannitol through intestinal caco-2 monolayers

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