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首页> 外文会议>International symposium on controlled release of bioactive materials;Consumer and diversified products conference >Targeted delivery of artificial viral envelopes to hep-G2 cells using a hepatocyte-spectific peptidic sequence from p.berghei
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Targeted delivery of artificial viral envelopes to hep-G2 cells using a hepatocyte-spectific peptidic sequence from p.berghei

机译：使用来自伯氏疟原虫的肝细胞特异性肽序列将人工病毒包膜靶向递送至hep-G2细胞

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The major barrier to the development of gene delivery systems remains the cell membrane. One way to circumvent this barrier is to emulate viral ways of entry into the cell. An example of this viral mimicry, the Artificial Viral Envelope (AVE~(TM)) approach, incorporates viral glycoproteins into a totally synthetic negatively charged lipid envelope of well defined composition, thereby alleviating possible toxicity from carry over f unwanted viral components into the final preparation. The first generation of AVE~(TM) used lipid compositions similar to that of the respiratory syncitial virus and HIV-I virus in which were incorporated either F and G glycoproteins or gp160, respectively (1-4). In the second generation of AVE~(TM) all components of viral origin have been removed. In this report we describe the anchoring of a synthetic hepatocyte-specific peptide from the sequence of the malaria sporozoite CS coat protein to target Hep-G2 cells in vitro.
机译：基因传递系统发展的主要障碍仍然是细胞膜。规避此障碍的一种方法是模拟病毒进入细胞的方式。这种病毒模仿的例子是人工病毒包膜（AVE_TM）方法，它把病毒糖蛋白掺入了成分明确的完全合成的带负电荷的脂质包膜中，从而减轻了将有害的病毒成分带入最终产物的可能的毒性。准备。第一代AVE TM使用与呼吸道合胞病毒和HIV-1病毒相似的脂质组合物，其中分别掺入了F和G糖蛋白或gp160（1-4）。在第二代AVE_TM中，病毒来源的所有成分均已被去除。在此报告中，我们描述了从疟疾子孢子CS外壳蛋白序列到体外靶向Hep-G2细胞的合成肝细胞特异性肽的锚定。

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