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首页> 外文会议>World multiconference on systemics, cybernetics and informatics;SCI 2000 >Autograft of Cryopreserved Cranial Bone Flap --Animal Model and Clinical Study
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Autograft of Cryopreserved Cranial Bone Flap --Animal Model and Clinical Study

机译：自体冷冻颅骨皮瓣的自体移植-动物模型与临床研究

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The purpose of this study was establish the technique of cryopreservation of cranial bone flaps for autografts. Eighteen Newzealand white rabbits were used as animal model. Cryopreserved flap was implanted back to the same animal after being thawed. According to the animal results, the cranial bone flap of patient suffering from craniocerebral trauma during decompression was cryo-preserved with the same method and placed back after the edima disappeaed. Total 31 patients undergoing the autograft of Cryopreserved cranial bone flaps. The flaps were Cryopreserved from 79 to 510 days (average 215 days). No rejection and inflammation occurred in any patient, dropsy occurred in 2 patients and disappeared after tapping and compression bandage treatment. By X-ray and CT examination, slight bone absorption occurred in the edge area of the flap after 1～2 months. After 4～6 months, the spatium became narrow, synostosis took place in most of the flap areas after 12 months. X-ray and ECT examination showing that the synostosis is excellent. In conclusion, based on animal study, we successfully Cryopreserved human cranial bone flaps for autograft, and the clinical outcome has been satisfactory. Cryopreservation of skull flap has no rejection occurs in patient after autograft. Psychologically, it is easier for the patient to accept this approach than any other articial materials as grafts. This method benefits the all patients and transplantation can be performed in schedule.
机译：这项研究的目的是建立冷冻保存自体移植颅骨皮瓣的技术。使用18只新西兰白兔作为动物模型。将冷冻保存的皮瓣融化后植入同一只动物。根据动物结果，用相同方法冷冻保存减压期间颅脑创伤患者的颅骨瓣，并在水肿消失后放回原处。共有31例患者接受了冷冻保存的颅骨皮瓣的自体移植。将皮瓣冷冻保存79至510天（平均215天）。在任何患者中均未发生排斥反应和炎症，在2例患者中出现了水肿，并在敲打和加压绷带治疗后消失。经X线及CT检查，术后1〜2个月皮瓣边缘区域出现少量骨吸收。 4〜6个月后，睑缘变窄，在12个月后大部分皮瓣部位发生骨突增生。 X射线和ECT检查显示骨突形成良好。总之，基于动物研究，我们成功地冷冻保存了用于自体移植的人颅骨皮瓣，临床效果令人满意。自体移植后患者的颅骨皮瓣冷冻保存未发生排斥反应。从心理上讲，患者比任何其他人工血管材料更容易接受这种方法。这种方法使所有患者受益，并且可以按计划进行移植。

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