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首页> 外文会议>Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE >A. database application for donor-recipient HLA match used in kidney transplantation
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A. database application for donor-recipient HLA match used in kidney transplantation

机译：A.肾脏移植中供体-受体HLA匹配的数据库应用

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The outcome of kidney transplants from unrelated live donors or from cadaver kidneys have been reported to be strongly influenced by HLA compatibility. Due to the difficulty of allocation of kidneys for identical HLA match, to increase patients' chances of receiving transplants, consequently, matching has been proposed of deduced amino acid residues of the individual HLA molecules shared by cross-reactive antigen groups (CREGs). Currently many hospitals in China use a serological method for HLA typing, some of them use DNA based technology for HLA typing. But most hospitals in China perform HLA matching manually. We have developed a database application system with a program which can quickly find the most suitable individuals in need of kidney transplants from the waiting list for an available donor. Besides 0-3 mismatch of HLA-A,B, and DR, the program works with a criteria of CREGs and permissible HLA-DR mismatch. We noticed some different definitions of CREGs in the literatures and some divergence of views about permissible mismatch concept, it is also our goal to evaluate above criteria with statistical clinical results. Our system also covers virtually all aspects to meet the requirements of most hospitals' urological departments. Its features include patient information management, various statistical reports, and so on. Currently it is in use at two famous hospitals in China.
机译：据报道，来自不相关的活体供体或尸体肾脏的肾脏移植的结果受到HLA相容性的强烈影响。由于难以为相同的HLA匹配分配肾脏，以增加患者接受移植的机会，因此，已经提出了交叉反应抗原基团（CREG）共有的单个HLA分子推导氨基酸残基的匹配方案。目前，中国许多医院使用血清学方法进行HLA分型，其中一些医院使用基于DNA的技术进行HLA分型。但是中国的大多数医院都手动执行HLA匹配。我们已经开发了一个数据库应用程序系统，该系统具有一个程序，该程序可以从等待名单中快速找到最适合需要肾脏移植的个体，以寻找可用的捐助者。除了HLA-A，B和DR的0-3不匹配之外，该程序还可以使用CREG和允许的HLA-DR不匹配的条件来工作。我们注意到文献中对CREG的一些不同定义，以及关于允许的不匹配概念的一些分歧，这也是我们用统计的临床结果评估上述标准的目标。我们的系统几乎涵盖了所有方面，可以满足大多数医院泌尿科的要求。其功能包括患者信息管理，各种统计报告等。目前，中国有两家著名的医院正在使用它。

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