INVESTIGATION OF THE PHYSICAL STABILITY AND GLASS TRANSITION TEMPERATURE OF GLASS SOLUTIONS PREPARED BY MELT EXTRUSION OF POORLY WATER-SOLUBLE DRUGS

机译：难溶性药物熔体挤出制备玻璃溶液的物理稳定性和玻璃化转变温度的研究

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Glass solutions of three poorly water-soluble drugs have been prepared by melt extrusion with PVP. The physical stability of these extrudates was assessed at different relative humidities and the impact of recrystallisation on dissolution measured. Comparison of the Tg values determined both theoretically and experimentally was used as a means to predict stability.

机译：三种水溶性差的药物的玻璃溶液已通过PVP熔融挤出制备。在不同的相对湿度下评估这些挤出物的物理稳定性，并测量重结晶对溶解的影响。理论上和实验上确定的Tg值的比较被用作预测稳定性的手段。

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《International symposium on controlled release of bioactive materials;Consumer diversified products conference》|2001年|p.768-769|共2页
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作者
A. Forster; J. Hempenstall; T. Rades;
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原文格式 PDF
正文语种
中图分类基础医学;
关键词
indomethacin; lacidipine; tolbutamide; PVP; physical stability; glass transition; gordon-taylor equation;

机译：消炎痛拉西地平甲苯磺丁酰胺PVP;物理稳定性玻璃化转变;戈登-泰勒方程;

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1. Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers. [J] . Forster A, Hempenstall J, Rades T Journal of Pharmacy and Pharmacology . 2001,第3期

机译：通过亲水性无定形聚合物熔融挤出制备的水溶性差的药物的玻璃溶液的表征。
2. Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability [J] . Alhalaweh Amjad, Alzghoul Ahmad, Mahlin Denny, International Journal of Pharmaceutics . 2015,第1期

机译：在高于和低于玻璃化转变温度下储存后，药物的物理稳定性：与玻璃形成能力的关系
3. Influence of manufacturing factors on physical stability and solubility of solid dispersions containing a low glass transition temperature drug [J] . Sakurai A., Sako K., Maitani Y. Chemical and Pharmaceutical Bulletin . 2012,第11期

机译：制造因素对含有低玻璃化转变温度药物的固体分散体的物理稳定性和溶解度的影响
4. Investigating the thermal stability of 1-3 piezoelectric composite transducers by varying the thermal conductivity and glass transition temperature of the polymeric filler material [C] . Parr, A.C.S., OLeary, . 2002

机译：通过更改聚合物填充材料的热导率和玻璃化转变温度来研究1-3个压电复合换能器的热稳定性
5. Development and characterization of polymeric drug delivery systems prepared by hot-melt extrusion: Solubility, stability, bioadhesion and mechanical studies. [D] . Deng, Weibin. 2012

机译：通过热熔挤出制备的聚合物药物递送系统的开发和表征：溶解性，稳定性，生物粘附性和力学研究。
6. Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability [O] . Amjad Alhalaweh, Ahmad Alzghoul, Denny Mahlin, -1

机译：在高于和低于玻璃化转变温度下储存后药物的物理稳定性：与玻璃形成能力的关系
7. Physical stability of drugs after storage above and below the glass transition temperature : Relationship to glass-forming ability [O] . Alhalaweh, Amjad, Alzghoul, Ahmad, Mahlin, Denny, 2015

机译：在高于和低于玻璃化转变温度下储存后，药物的物理稳定性：与玻璃形成能力的关系

INVESTIGATION OF THE PHYSICAL STABILITY AND GLASS TRANSITION TEMPERATURE OF GLASS SOLUTIONS PREPARED BY MELT EXTRUSION OF POORLY WATER-SOLUBLE DRUGS

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