PRE-CLINICAL AND CLINICAL INVESTIGATION OF THE SAFETY AND IMMUNOGENICITY OF A NOVEL INTRANASAL INFLUENZA VACCINE

机译：新型鼻内流感疫苗的安全性和免疫原性的临床前和临床调查

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Nasalflu, developed by the Swiss Serum and Vaccine Institute, is a novel, highly immunogenic and safe influenza subunit vaccine which is easily administered as a nasal spray. The results of preclinical studies in ferrets, baboons, minipigs, mice and rabbits are presented here, and issues concerning route of administration, mechanism of action (preventing the disease and halting further spread of the disease), and the specific safety issues of the adjuvant itself (possible neurological activity of HLT) are examined. This new route of administration is likely to increase compliance to vaccination, and could become an important tool to promote vaccination in population groups which show high resistance to vaccination.

机译：由瑞士血清和疫苗研究所开发的Nasalflu是一种新型，高度免疫原性和安全性的流感亚单位疫苗，可轻松作为鼻喷雾剂施用。本文介绍了对雪貂，狒狒，小型猪，小鼠和兔子的临床前研究结果，以及有关给药途径，作用机理（预防疾病和阻止疾病进一步传播）以及佐剂的特殊安全性问题本身（可能的HLT的神经活动）进行了检查。这种新的给药途径可能会提高对疫苗接种的依从性，并可能成为促进对疫苗表现出高度抵抗力的人群进行疫苗接种的重要工具。

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《International symposium on controlled release of bioactive materials;Consumer diversified products conference》|2001年|p.79-80|共2页
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R. Glueck;
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中图分类基础医学;
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nasalflu; virosomes; influenza; intranasal; vaccine; HLT;

机译：鼻流感病毒体流感;鼻内疫苗; HLT;

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1. A randomized, double-blind, controlled clinical trial to evaluate the safety and immunogenicity of an intranasally administered trivalent inactivated influenza vaccine with adjuvant LTh(alpha K): A phase I study [J] . Pan Sung-Ching, Hsieh Szu-Min, Lin Chih-Feng, Vaccine . 2019,第14期

机译：随机的双盲，受控临床试验，以评估用佐剂Lth（αK）的鼻内给药的三价灭活流感疫苗的安全性和免疫原性：我研究的一部分
2. Immunogenicity and safety of an egg-based inactivated quadrivalent influenza vaccine (GC3110A) versus two inactivated trivalent influenza vaccines with alternate B strains: A phase 2162; randomized clinical trial in adults [J] . Song Joon Young, Lee Jacob, Woo Heung Jeong, Human vaccines & immunotherapeutics. . 2019,第3期

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3. Immunogenicity and safety of an inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccines in participants >/=3 years of age: a double-blind, randomized, parallel-controlled phase III clinical trial in China [J] . Wang Shi-Yuan, Liu Shu-Zhen, Chu Kai, Expert review of vaccines . 2017,第7a12期

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4. N,N,N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administration [C] . Annual meeting exposition of the Controlled Release Society . 2009

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5. The Administration of Intranasal Live Attenuated Influenza Vaccine Induces Changes in the Nasal Microbiota and Nasal Epithelium Gene Expression Profile. [D] . Tarabichi, Yasir. 2015

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PRE-CLINICAL AND CLINICAL INVESTIGATION OF THE SAFETY AND IMMUNOGENICITY OF A NOVEL INTRANASAL INFLUENZA VACCINE

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