TARGETING THE SODIUM DEPENDENT MULTIVITAMIN TRANSPORTER (SMVT) IN THE BLOOD-BRAIN BARRIER (BBB) TO INCREASE THE TRANSPORT OF BIOTIN CONJUGATED PEPTIDES AND POLYMERS

机译：在血脑屏障（BBB）中定位依赖钠的多维生素转运蛋白（SMVT）以增加生物素共轭肽和聚合物的转运

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

The uptake of biotin in an in vitro model of the BBB was characterized in order to assess the suitability of targeting SMVT to deliver biotin-conjugated compounds to the brain. The SMVT-mediated transport of R.I-C(biotin)-Tat9, a biotin conjugated anti-HIV-1 nonapeptide, across the BBB was evaluated. Further, the use of various branched biotin-PEGs (polyethylene glycols) as therapeutic drug carriers was studied.

机译：为了评估靶向SMVT将生物素共轭化合物递送至大脑的适用性，对BBB体外模型中生物素的摄取进行了表征。评估了SMVT介导的R-I-C（生物素）-Tat9，一种生物素结合的抗HIV-1九肽跨BBB的转运。此外，研究了各种支链生物素-PEG（聚乙二醇）作为治疗药物载体的用途。

著录项

来源
《International symposium on controlled release of bioactive materials;Consumer diversified products conference》|2001年|p.243-244|共2页
会议地点
作者
S. Park; S. Stein; P. J. Sinko;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类基础医学;
关键词
brain targeted delivery; BBB; BBMEC; peptide delivery; transporter; polymer conjugates;

机译：脑靶向递送; BBB; BBMEC;肽递送;运输者聚合物共轭物;

相似文献

外文文献
中文文献
专利

1. Blood-to-retina transport of biotin via Na+-dependent multivitamin transporter (SMVT) at the inner blood-retinal barrier. [J] . Ohkura Y, Akanuma S, Tachikawa M, Experimental Eye Research . 2010,第3期

机译：生物素通过钠+依赖性多种维生素转运蛋白（SMVT）在血液-视网膜的内部血液到视网膜的转运。
2. Biotin uptake by T47D breast cancer cells: Functional and molecular evidence of sodium-dependent multivitamin transporter (SMVT) [J] . VadlapudiA.D., VadlapatlaR.K., PalD., International Journal of Pharmaceutics . 2013,第1a2期

机译：T47D乳腺癌细胞对生物素的吸收：钠依赖性多种维生素转运蛋白（SMVT）的功能和分子证据
3. Sodium dependent multivitamin transporter (SMVT): A potential target for drug delivery [J] . VadlapudiA.D., VadlapatlaR.K., MitraA.K. Current drug targets-The International journal for timely in-depth reviews on drug targets . 2012,第7期

机译：钠依赖性多种维生素转运蛋白（SMVT）：药物输送的潜在目标
4. Increasing the transport of a 9-amino acid Tat-inhibitor using a poly(ethylene glycol) biopolymer targetting the sodium dependent multivitamin transporter [C] . S.Ramanathan, S.Stein, P.Prasad, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：使用靶向钠依赖性多种维生素转运蛋白的聚乙二醇生物聚合物，增加9-氨基酸Tat抑制剂的转运
5. Targeted brain delivery of novel nanoparticles via the blood-brain barrier thiamine transporter. [D] . Lockman, Paul Richard. 2003

机译：通过血脑屏障硫胺素转运蛋白的靶向脑部递送。
6. Sodium Dependent Multivitamin Transporter (SMVT): A Potential Target for Drug Delivery [O] . Aswani Dutt Vadlapudi, Ramya Krishna Vadlapatla, Ashim K. Mitra -1

机译：钠依赖性多酰胺转运蛋白（SMVT）：药物递送的潜在靶标
7. Sodium Dependent Multivitamin Transporter (SMVT): A Potential Target for Drug Delivery [O] . Aswani Dutt Vadlapudi, Ramya Krishna Vadlapatla, Ashim K. Mitra 2012

机译：钠依赖性多酰胺转运蛋白（SMVT）：药物递送的潜在靶标
8. Combined Exposure to Pyridostigmine Bromide (PB), DEET, and Permethrin with Stress Increases Blood-Brain Barrier (BBB) Permeability and Inhibits Brain Acetycholinesterase in Rats. [R] . Abou-Donia, M. B., Khan, W. A., Suliman, H. B., 2001

机译：联合暴露于吡啶斯的明溴化物（pB），DEET和氯菊酯与应激增加血脑屏障（BBB）渗透性和抑制大鼠脑乙酰胆碱酯酶。

TARGETING THE SODIUM DEPENDENT MULTIVITAMIN TRANSPORTER (SMVT) IN THE BLOOD-BRAIN BARRIER (BBB) TO INCREASE THE TRANSPORT OF BIOTIN CONJUGATED PEPTIDES AND POLYMERS

摘要

著录项

相似文献

相关主题

期刊订阅