• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International symposium on controlled release of bioactive materials;Consumer diversified products conference >PREPARATION AND IN VITRO EVALUATION OF SOLID LIPID NANORODS CONTAINING ANTIVIRAL AGENT, ACYCLOVIR SODIUM SALT
【24h】

PREPARATION AND IN VITRO EVALUATION OF SOLID LIPID NANORODS CONTAINING ANTIVIRAL AGENT, ACYCLOVIR SODIUM SALT

机译：含抗病毒剂，无环藻酸钠盐的固体脂质纳米粒的制备及体外评价

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The shape and particle size of acyclovir sodium salt containing biocompatible, biodegradable and intravenously administrable sub-micron colloidal particles were investigated. Slow release, of acyclovir sodium salt was also studied. These colloidal particles resembled in rods in shape and had about 1 micron of length. The nanorods, composed of a fatty acid core, surrounded with a phospholipidic shell, were prepared, and the in vitro release of the drug in a solution of pH 7.4 at 25 DGC was investigated. The release of acyclovir sodium salt from the nanorods followed a bimodal pattern. In the first stage, the release process was fast and near to 20% of the drug was released within 75 minutes, whereas during a later stage the release was rather lent. This last stage followed a zero order-like pattern. Probably, the former stage was governed by desorption of the adsorbed drug from the surface and the later one was mainly controlled by mechanisms of both drug partition and diffusion from the core and shell.
机译：研究了含有生物相容性，可生物降解和静脉内施用的亚微米胶体颗粒的阿昔洛韦钠盐的形状和粒径。还研究了阿昔洛韦钠盐的缓慢释放。这些胶体颗粒的形状类似于棒状，长度约为1微米。制备了由脂肪酸核组成，被磷脂壳包围的纳米棒，并在25 DGC下研究了该药物在pH 7.4溶液中的体外释放。阿昔洛韦钠盐从纳米棒中的释放遵循双峰模式。在第一阶段，释放过程很快，在75分钟内释放了将近20％的药物，而在随后的阶段，释放则相当缓慢。最后一个阶段遵循零阶模式。前一个阶段可能是由吸附的药物从表面解吸控制的，后一个阶段主要是受药物分配和从核和壳扩散的机制所控制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号