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Epigenetic programming: an approach of embedding epigenetic learning via modification of histones in genetic programming

机译：表观遗传编程：通过修饰基因组中的组蛋白来嵌入表观遗传学习的方法

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Extending the notion of inheritable genotype in genetic programming (GP) from the common model of DNA into chromatin (DNA and histones), we propose epigenetic programming as an approach, embedding an explicitly controlled gene expression via modification of histones in GP. We propose double cell representation of the simulated individuals, comprising somatic cell and germ cell, both represented by their respective chromatin structures. Following biologically plausible concepts, we regard the plastic phenotype of the somatic cell, achieved via controlled gene expression owing to modifications to histones (epigenetic learning, EL) as relevant for fitness evaluation, while the genotype of the germ cell - to the phylogenesis of the individuals. The approach is verified on evolution of social behavior of team of predator agents in predator-prey pursuit problem. The empirically obtained performance evaluation results indicate that EL contributes to more than 2-fold improvement of computational effort of the phylogenesis via GP. We view the cause for that in the cumulative effect of polyphenism and epigenetic stability. The former allows for phenotypic diversity of genotypically similar individuals, while the latter robustly preserves the individuals from the destructive effects of crossover by silencing of certain genotypic combinations and explicitly activating them only when they are most likely to be expressed in corresponding beneficial phenotypic traits.
机译：将遗传编程（GP）中的可遗传基因型概念从普通的DNA模型扩展到染色质（DNA和组蛋白）中，我们提出表观遗传编程作为一种方法，通过修饰GP中的组蛋白来嵌入明确控制的基因表达。我们提出了模拟个体的双细胞代表，包括体细胞和生殖细胞，均由它们各自的染色质结构代表。遵循生物学上合理的概念，我们认为由于对组蛋白的修饰（表观遗传学习，EL）而通过控制基因表达而获得的体细胞的可塑性表型与适应性评估有关，而生殖细胞的基因型对小鼠的系统发育具有重要意义。个人。验证了该方法对捕食者—猎物追捕问题中捕食者团队社会行为演化的影响。根据经验获得的性能评估结果表明，EL有助于通过GP进行系统发育的计算工作量提高2倍以上。我们认为原因在于多态性和表观遗传稳定性的累积效应。前者允许基因型相似的个体的表型多样性，而后者通过沉默某些基因型组合并仅当它们最有可能以相应的有益表型性状表达时才明确激活它们，从而使个体免受交叉破坏性影响。

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