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首页> 外文会议>第四届国际后基因组生命科学技术学术论坛 >ANALYSIS OF IL-1B-511 and IL-1B-31 POLYMORPHISMS ON SUSCEPTIBILITY TO TUBERCULOSIS
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ANALYSIS OF IL-1B-511 and IL-1B-31 POLYMORPHISMS ON SUSCEPTIBILITY TO TUBERCULOSIS

机译：IL-1B-511和IL-1B-31多态性对结核病易感性的分析

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The aim of this study was to test whether the IL - 1β gene promoter region polymorphisms could be useful genetic markers for susceptibility to patients with tuberculosis (TB). A normal control group of 105 healthy people and another group of 98 patients with TB (40 pulmonary TB, 28 pulmonary TB with extrapulmonary TB and 30 extrapulmonary TB) were examined. PCR-restriction fragment length polymorphism(PCR-RFLP) analysis was done for the IL- 1β gene polymorphisms (-31 and -511) using endonucleases AluI and AvaI, respectively. The frequencies of IL- 1β-511 gene were not statistically different between controls and all patients with TB(P＞0.05). There were an increases in both-31 T alleles and TT genotypes frequencies in all patients with TB compared to controls (54.1 vs 42.4%, OR= 1.60, P=0.018 and 33. 7 vs 10. 5%, OR=4.34, P=0.0001, respectively), and a specific decrease in - 31 CT genotype frequency (40. 8 vs 63. 8%, OR=0.39, P=0.001). The pulmonary TB or extrapulmonary TB carrying -31 TT genotype showed a significant increased risk (OR=3.66, P=0.004 and OR=7.48, P=0.00001, respectively) compared with controls, but- 31 CT genotype was associated with a decreased risk of pulmonary TB and extrapulmonary TB (OR=0.34, P=0.004 and OR=0.38. P=0.02, respectively). The results indicate that IL -1β-31 TT genotype had a significant increased risk and IL - 1β- 31CT genotype had a significant decreased risk in pulmonary TB or extrapulmonary TB compared with controls.
机译：这项研究的目的是检验IL-1β基因启动子区多态性是否可以作为结核病（TB）患者易感性的有用遗传标记。检查了一个正常的对照组，即105名健康人和另一组98例TB患者（40例肺结核，28例肺外结核合并肺外结核和30例肺外结核）。分别使用核酸内切酶AluI和AvaI对IL-1β基因多态性（-31和-511）进行了PCR限制性片段长度多态性（PCR-RFLP）分析。对照组与所有TB患者的IL-1β-511基因频率无统计学差异（P＞ 0.05）。与对照组相比，所有结核病患者的31个T等位基因和TT基因型频率均增加（54.1 vs 42.4％，OR = 1.60，P = 0.018和33. 7 vs 10. 5％，OR = 4.34，P分别= 0.0001）和-31个CT基因型频率的特定降低（40. 8比63.8％，OR = 0.39，P = 0.001）。肺结核或肺外结核携带-31 TT基因型与对照组相比，风险显着增加（OR = 3.66，P = 0.004和OR = 7.48，P = 0.00001），但是-31 CT基因型与降低的风险相关肺结核和肺外结核的发生率（分别为OR = 0.34，P = 0.004和OR =0.38。P= 0.02）。结果表明，与对照组相比，IL-1β-31TT基因型的患肺结核或肺外结核的风险显着增加，IL-1β-31CT基因型的患病风险显着降低。

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