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首页> 外文会议>Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets >Expression of Leptin, Leptin Receptor, and Hypoxia-Inducible Factor 1α in Human Endometrial Cancer
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Expression of Leptin, Leptin Receptor, and Hypoxia-Inducible Factor 1α in Human Endometrial Cancer

机译：瘦素，瘦素受体和缺氧诱导因子1α在子宫内膜癌中的表达

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Recent studies suggested that Ob (Ob) and its receptor (ObR) could be involved in the pathogenesis of various human malignancies, among others in endometrial cancer. Moreover, hypoxia, which is associ ated with solid tumors, might stimulate, through hypoxia-inducible fac tor 1α (HIF-1α), expression of Ob and ObR. In this article, we analyzed by immunohistochemistry the expression of Ob, ObR, and HIF-1α in 60 cases of human endometrial cancer tissues as well as in 25 cases of normal endometria. Additionally, we assessed correlations among studied pro teins as well as relationships with selected clinicopathological features of endometrial cancer. Immunoreactivity for Ob, ObR, and HIF 1α pro tein was observed in 56.7%, 30.0%, and 78.3% of endometrial cancers, respectively. The expression of HIF-1α showed a significant positive cor relation with Ob (P ＜ 0.0001, r = 0.573) and ObR (P = 0.020, r = 0.299). Moreover, we noted positive correlation between Ob and ObR (P = 0.001, r = 0.429). No statistically significant relationship was re vealed between Ob, ObR, and HIF-1α protein in regard to patient's age, histological grade, and extent of tumor growth (pT). In conclusion, HIF-1α, which is related to tissue hypoxia in endometrial cancer, seems to be associated with overexpression of Ob and ObR. Ob could exert autocrine effect to stimulate endometrial cancer progression. Thus the autocrine Ob loop should be taken into consideration as a novel potential target in endometrial cancer prevention and treatment.
机译：最近的研究表明，Ob（Ob）及其受体（ObR）可能参与各种人类恶性肿瘤的发病机制，尤其是子宫内膜癌。此外，与实体瘤相关的缺氧可能通过缺氧诱导因子1α（HIF-1α）刺激Ob和ObR的表达。在本文中，我们通过免疫组织化学分析了60例人子宫内膜癌组织和25例正常子宫内膜癌组织中Ob，ObR和HIF-1α的表达。此外，我们评估了研究蛋白之间的相关性以及与子宫内膜癌的选定临床病理特征之间的关系。分别在56.7％，30.0％和78.3％的子宫内膜癌中观察到针对Ob，ObR和HIF1α蛋白的免疫反应性。 HIF-1α的表达与Ob（P <0.0001，r = 0.573）和ObR（P = 0.020，r = 0.299）呈显着正相关。此外，我们注意到Ob与ObR之间呈正相关（P = 0.001，r = 0.429）。关于患者的年龄，组织学等级和肿瘤生长程度（pT），Ob，ObR和HIF-1α蛋白之间没有发现统计学上的显着相关性。总之，与子宫内膜癌组织缺氧有关的HIF-1α似乎与Ob和ObR的过表达有关。 Ob可以发挥自分泌作用来刺激子宫内膜癌的进展。因此，自分泌Ob环应被视为子宫内膜癌预防和治疗中的新型潜在靶标。

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