• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets >Lack of Association of the Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Gene Polymorphism with Risk of Cervical Cancer in Korean Population
【24h】

Lack of Association of the Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Gene Polymorphism with Risk of Cervical Cancer in Korean Population

机译：朝鲜族人群中环氧合酶-2和诱导型一氧化氮合酶基因多态性与宫颈癌风险的关联缺乏

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Currently, many studies have shown that nitric oxide (NO) and prostaglandin (PG) are main inflammatory mediators involved in a variety of pathophysiological processes including inflammation and carcinogenesis. In this article, we explored the possible association of polymorphisms, of two representative inflammatory mediators, with the risk for cervical cancer. This study included 176 cases of histologically confirmed invasive cervical cancer, and 172 healthy controls. Allele fre quency of 12 single-nucleotide polymorphisms (SNPs) of cyclooxygenase-2 (COX-2) and COX5 of the inducible nitric oxide synthase (iNOS) genes in 43 different normal populations were analyzed. We found that 14 of 17 showed a monomorphic or minimal minor allele frequency; therefore, we did not continue with additional analysis. Three SNPs (2 for COX-2,1 for iNOS) were chosen for the study. Genotyping of three SNPs (SNP-rs5275 in the untranslated region of exon 10 and rs5277 in the coding region of exon 3 of COX-2, and iNOS Ser~(608) Leu allele C/T polymorphism within exon 16 of the iNOS reductase domain) was performed. No significant increase was found in any of the genotypes of the COX-2 or iNOS in the cancer group. We investigated the possible correlation between the genotypes and the clinicopathologic parameters of cervical cancer. No significant association of the genotypes studied was found with respect to clinical stage, lymph node (LN) status, histologic type, or parametrial invasion. Our data did not reveal an association between COX-2 and iNOS polymorphisms with cervical cancer in Korean women.
机译：目前，许多研究表明，一氧化氮（NO）和前列腺素（PG）是涉及多种病理生理过程（包括炎症和致癌作用）的主要炎症介质。在本文中，我们探讨了两种代表性炎性介质多态性与宫颈癌风险的可能关联。这项研究包括176例经组织学证实为浸润性宫颈癌的病例和172例健康对照者。分析了43个正常人群中环氧合酶2（COX-2）和诱导型一氧化氮合酶（iNOS）基因的COX5的12个单核苷酸多态性（SNPs）的等位基因频率。我们发现17个中的14个显示出单态或最小的次要等位基因频率。因此，我们没有继续进行其他分析。本研究选择了三个SNP（COX-2为2个，iNOS为1个）。在COX-2外显子3的外显子10的非翻译区和rs5277的三个SNPs的基因分型，以及iNOS还原酶结构域第16外显子的iNOS Ser〜（608）Leu等位基因C / T多态性）进行。在癌症组中，未发现任何COX-2或iNOS基因型的显着增加。我们调查了基因型与宫颈癌临床病理参数之间可能的相关性。在临床分期，淋巴结（LN）状态，组织学类型或子宫旁膜炎方面，未发现所研究的基因型之间有显着相关性 入侵。我们的数据未揭示韩国女性中COX-2和iNOS多态性与宫颈癌之间的关联。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号